Personalized approach to treating persistent atrial fibrillation
Personalized Persistent Atrial Fibrillation Ablation: The PeAF-BY-LAWT Trial
NA · Centro Medico Teknon · NCT05396534
This study is testing a new personalized method for treating persistent atrial fibrillation to see if it can improve outcomes for patients compared to the standard approach.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 156 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centro Medico Teknon (other) |
| Locations | 1 site (Barcelona) |
| Trial ID | NCT05396534 on ClinicalTrials.gov |
What this trial studies
This trial investigates a personalized protocol for catheter ablation of persistent atrial fibrillation (PeAF) using a contact-force catheter and a multichannel radiofrequency generator. The approach aims to adapt the ablation index target based on integrated left atrial wall thickness (LAWT) information, comparing its safety and efficacy to the established CLOSE protocol. The study focuses on improving long-term outcomes for patients with PeAF, which historically have been less satisfactory than those for paroxysmal atrial fibrillation. Participants will undergo pulmonary vein isolation (PVI) as a primary treatment strategy.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who require ablation for persistent atrial fibrillation.
Not a fit: Patients under 18, pregnant women, or those with previous AF procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved long-term outcomes and symptom relief for patients with persistent atrial fibrillation.
How similar studies have performed: Previous studies have shown promising results with similar catheter ablation techniques, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years. * Indication for persistent atrial fibrillation ablation. * Signed informed consent Exclusion Criteria: * Age \< 18 years. * Pregnancy. * Previous AF redo procedure. * Impossibility to perform a pre-procedural CT scan. * Concomitant investigation treatments. * Medical, geographical and social factors that make study participation impractical, and inability to give written informed consent. Patient's refusal to participate in the study.
Where this trial is running
Barcelona
- Teknon Medical Center — Barcelona, Spain (RECRUITING)
Study contacts
- Study coordinator: Antonio Berruezo, MD, PhD
- Email: antonio.berruezo@quironsalud.es
- Phone: 669761263
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Persistent Atrial Fibrillation, Persistent Atrial Fibrillation Longstanding, Atrial Fibrillation, Catheter Ablation, Multidetector Computed Tomography