Persistent fatigue after infection: a look at why fatigue lingers
Official title: Mechanisms of Persistent Fatigue (MAP-FAT): A Prospective Observational Cohort Study of Persistent Fatigue Following Epstein-Barr Virus Infection in Adolescents and Young Adults
Run by University Hospital, Akershus · NCT07394855 · Data updated 2026-11-12
This observational study tests why persistent fatigue happens after infections like EBV and Long COVID, to understand the mechanisms in people who still feel tired weeks after symptoms begin.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years to 39 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University Hospital, Akershus Academic / other |
| Locations | 1 site (Lørenskog) |
| Status | Recruiting |
| Started | April 28, 2026 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | May 22, 2026 |
| Trial ID | NCT07394855 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with laboratory-confirmed EBV infection whose fatigue symptoms began 3 to 6 weeks ago and who do not have major comorbidities or ongoing life stressors.
✕Probably not a fit
People with significant co-morbidities, ongoing major health issues, or recent high-demand life events may see little direct benefit from this observational analysis.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the mechanisms behind persistent fatigue following acute infection, including potential interactions between brain function, immune responses, and autonomic nervous system signaling. It focuses on people with fatigue after viral infections, such as EBV, with inclusion of those whose first symptoms began between 3 and 6 weeks ago. Researchers will describe clinical features and explore underlying biological pathways without testing an intervention. The study is conducted at Akershus University Hospital and aims to improve understanding of PF to inform future treatment strategies.
Why it matters
Potential benefit: Gaining a clearer understanding of why fatigue persists after infection could guide future therapies and management strategies for patients experiencing long-lasting fatigue.
How similar studies have gone: Previous research suggests that studying post-infectious fatigue can reveal meaningful patterns, though the exact mechanisms remain incompletely understood and this study adds regional data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria (pertaining to EBV group only): * EBV infection, laboratory confirmed. * First symptoms \> 3 and \< 6 weeks away Exclusion Criteria (pertaining to both groups) * Co-morbidity, including mental illness (seasonal allergy/asthma is accepted if no signs/symptoms) * Usage of pharmaceuticals (hormonal contraception and paracetamol/ibuprofen is accepted) * Concurrent demanding life event causing fatigue. * Disability impacting on daily living. * Regular smoking * Usage of illicit drugs * Pregnancy
Where it's running
-
Akershus University Hospital
Lørenskog, Norway Recruiting
Study contacts
- Study coordinator: Vegard Bruun Bratholm Wyller
- Email: v.b.b.wyller@medisin.uio.no
- Phone: +4791166681
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Understanding and treating fatigue in primary care patients
This study is testing a new online therapy for fatigue to see if it helps people in primary care feel better compared to regular treatment.
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Yoga vs Health Education for Persistent Post-COVID Fatigue
This trial will test whether adding a structured yoga program or health education to routine care helps reduce persistent fatigue in adults who had COVID-19.
-
Investigating COVID-19 in hospitalized children in Norway
This study looks at how COVID-19 affects children in hospitals in Norway to see what makes some kids sicker than others and to understand the long-term effects of the virus.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.