Yoga vs Health Education for Persistent Post-COVID Fatigue
Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome
This trial will test whether adding a structured yoga program or health education to routine care helps reduce persistent fatigue in adults who had COVID-19.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | University Hospital Tuebingen Academic / other |
| Locations | 1 site (Stuttgart) |
| Trial ID | NCT05890599 on ClinicalTrials.gov |
What this trial studies
This interventional trial compares a structured yoga program plus routine care with health education plus routine care in adults with persistent fatigue after COVID-19. Eligible participants are 18–65 years old with confirmed prior COVID-19, at least 12 weeks of ongoing symptoms, and a Chalder Fatigue Scale score ≥4, while those with other medical causes of fatigue, significant physical limitations, pregnancy/breastfeeding, or current yoga practice are excluded. Interventions are delivered in person at the trial site with short- and medium-term follow-up to measure changes in fatigue. The primary outcome is change in fatigue severity using the Chalder Fatigue Scale, with likely secondary measures of function and quality of life.
Who should consider this trial
Good fit: Adults aged 18–65 with a confirmed COVID-19 infection at least 12 weeks earlier who report ongoing fatigue (Chalder score ≥4) and can participate in yoga are ideal candidates.
Not a fit: People whose fatigue is clearly due to other medical conditions, who have physical limitations preventing yoga, who are pregnant or breastfeeding, or who already practice yoga regularly are unlikely to benefit from or qualify for this intervention.
Why it matters
Potential benefit: If successful, this could provide a low-risk, non-drug option to reduce persistent fatigue after COVID-19.
How similar studies have performed: Similar mind–body programs and yoga have shown modest benefits for chronic and cancer-related fatigue in small trials, but high-quality evidence specific to post‑COVID fatigue is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed COVID-19 diagnosis * Follow-up symptoms of ≥ 12 weeks * Persistent fatigue (scores ≥4 on the binomial Chalder Fatigue Scale). * Self-assessment that fatigue was a consequence of COVID-19 disease * Age 18-65 years Exclusion Criteria: * Chronic medical conditions or regular use of medications associated with fatigue * Indication of health cause of fatigue other than post-COVID. * Indication of other factors as the main cause of fatigue * Physical limitations that do not allow participation in the yoga intervention * Pregnancy, breastfeeding * Concurrent participation in other clinical trials * Current yoga practice
Where this trial is running
Stuttgart
- Bosch-Health-Campus — Stuttgart, Germany (Recruiting)
Study contacts
- Study coordinator: Holger Cramer, Professor
- Email: yasemin.anguelov@bosch-health-campus.com
- Phone: +49 711 8101 7858
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.