Yoga vs Health Education for Persistent Post-COVID Fatigue
Official title: Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome
Run by University Hospital Tuebingen · NCT05890599 · Data updated 2026-11-12
This trial will test whether adding a structured yoga program or health education to routine care helps reduce persistent fatigue in adults who had COVID-19.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital Tuebingen Academic / other |
| Locations | 1 site (Stuttgart) |
| Status | Recruiting |
| Started | June 10, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | March 31, 2026 |
| Registry record updated | July 10, 2025 |
| Trial ID | NCT05890599 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with a confirmed COVID-19 infection at least 12 weeks earlier who report ongoing fatigue (Chalder score ≥4) and can participate in yoga are ideal candidates.
✕Probably not a fit
People whose fatigue is clearly due to other medical conditions, who have physical limitations preventing yoga, who are pregnant or breastfeeding, or who already practice yoga regularly are unlikely to benefit from or qualify for this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional trial compares a structured yoga program plus routine care with health education plus routine care in adults with persistent fatigue after COVID-19. Eligible participants are 18–65 years old with confirmed prior COVID-19, at least 12 weeks of ongoing symptoms, and a Chalder Fatigue Scale score ≥4, while those with other medical causes of fatigue, significant physical limitations, pregnancy/breastfeeding, or current yoga practice are excluded. Interventions are delivered in person at the trial site with short- and medium-term follow-up to measure changes in fatigue. The primary outcome is change in fatigue severity using the Chalder Fatigue Scale, with likely secondary measures of function and quality of life.
Why it matters
Potential benefit: If successful, this could provide a low-risk, non-drug option to reduce persistent fatigue after COVID-19.
How similar studies have gone: Similar mind–body programs and yoga have shown modest benefits for chronic and cancer-related fatigue in small trials, but high-quality evidence specific to post‑COVID fatigue is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed COVID-19 diagnosis * Follow-up symptoms of ≥ 12 weeks * Persistent fatigue (scores ≥4 on the binomial Chalder Fatigue Scale). * Self-assessment that fatigue was a consequence of COVID-19 disease * Age 18-65 years Exclusion Criteria: * Chronic medical conditions or regular use of medications associated with fatigue * Indication of health cause of fatigue other than post-COVID. * Indication of other factors as the main cause of fatigue * Physical limitations that do not allow participation in the yoga intervention * Pregnancy, breastfeeding * Concurrent participation in other clinical trials * Current yoga practice
Where it's running
-
Bosch-Health-Campus
Stuttgart, Germany Recruiting
Study contacts
- Study coordinator: Holger Cramer, Professor
- Email: yasemin.anguelov@bosch-health-campus.com
- Phone: +49 711 8101 7858
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
How your daily body clock relates to breathing, activity, and nutrition after COVID-19
This project tests whether morning, intermediate, or evening circadian types relate to respiratory muscle strength, physical activity, sleep, and eating habits in adults with post-COVID-19 syndrome.
-
Persistent fatigue after infection: a look at why fatigue lingers
This observational study tests why persistent fatigue happens after infections like EBV and Long COVID, to understand the mechanisms in people who still feel tired weeks after symptoms begin.
-
Kneipp cold-water hydrotherapy for people with Long COVID
This randomized trial will test whether regular Kneipp cold-water hydrotherapy can improve quality of life for people with Post‑COVID Syndrome.
-
Functional inspiratory muscle and core stabilization training for people with post-COVID-19 syndrome
This trial will test whether adding inspiratory muscle training to core stabilization helps adults with post-COVID-19 syndrome improve breathing strength, trunk endurance, exercise capacity, and symptoms like fatigue and breathlessness.
-
Understanding and treating fatigue in primary care patients
This study is testing a new online therapy for fatigue to see if it helps people in primary care feel better compared to regular treatment.
-
Using Transcranial Pulse Stimulation to treat Post-COVID-19 symptoms
This study is testing if a new brain stimulation treatment can help people with lingering neurological symptoms after COVID-19, like fatigue and memory issues.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.