Periprosthetic Joint Infection After Hip or Knee Replacement: Causes and Prevention
Official title: Analysis of the Etiopathogenesis of Postoperative Complications in the Orthopedic Profile of Moscow Using the Example of Knee and Hip Arthroplasty and the Development of an Algorithm for the Diagnosis and Prevention of These Complications
Run by People's Friendship University of Russia · NCT07813832 · Data updated 2026-11-12
This study tests whether certain factors before and after hip or knee replacement help predict and prevent peri-implant infections in adults 45 and older.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years and up |
| Sex | All |
| Enrollment | 750 (estimated) |
| Sponsor | People's Friendship University of Russia Academic / other |
| Locations | 1 site (Moscow) |
| Status | Recruiting |
| Started | March 20, 2026 |
| Main results expected | March 20, 2027 |
| Study ends | May 20, 2029 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT07813832 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 45 years and older scheduled for hip or knee arthroplasty, with specified primary or secondary osteoarthritis conditions, who consent to long-term follow-up.
✕Probably not a fit
Patients with current knee or hip infection or those unable to commit to a 3-year follow-up may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study follows patients undergoing knee or hip arthroplasty to explore how mineral balance, overall health, and immune status relate to the risk of peri-implant infection. It includes morphological analysis of bone tissue at the implantation site and, for those with peri-implantitis, examines the surrounding microbiota. The goal is to describe how often infections occur and identify potential predictors to inform prevention strategies in Russia. Data will be collected before and after surgery over several years to assess long-term outcomes.
Why it matters
Potential benefit: Identifying predictors of infection could lead to targeted prevention and earlier intervention for patients undergoing joint replacement.
How similar studies have gone: Prior research has shown that infection after joint replacement is a significant issue; this study aims to build on limited regional data with a large prospective approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients 45 years and older * Clinical diagnosis: Idiopathic coxarthrosis stage 3 * Clinical diagnosis: Secondary coxarthrosis stage 3 (ANFH, post-traumatic coxarthrosis, rheumatoid arthritis, etc.) * Clinical diagnosis: Idiopathic gonarthrosis stage 3 * Clinical diagnosis: Secondary gonarthrosis stage 3 (aseptic necrosis, post-traumatic gonarthrosis, rheumatoid arthritis, etc.) Exclusion Criteria: * Patients with knee and/or hip joint infection * Patient refusal to participate in the study * Inability to follow up for 3 years * History of psychiatric illness * Decompensated somatic illness
Where it's running
-
City clinical Hospital №31
Moscow, Russia Recruiting
Study contacts
- Study coordinator: Asadula R. Abasov
- Email: asadula_abasov@mail.ru
- Phone: +7 930 416 7411
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.