Night-to-night variability of physiological markers in home sleep apnea testing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study analyzes night-to-night variability of traditional and newer physiological metrics collected during home sleep apnea testing. It aims to identify reliable markers that consistently reflect the impact of sleep apnea on the body, beyond the apnea-hypopnea index. Metrics under consideration include hypoxic burden, ventilatory burden, heart rate variability, autonomic arousals, and the pulse wave amplitude drop index. Findings could inform diagnostic practices and risk stratification for cardiovascular outcomes. The study is conducted at Inselspital and University of Bern in Switzerland with adult participants who meet the German guidelines for home sleep testing and have not used sleep therapies recently.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with suspected or diagnosed sleep-disordered breathing, irrespective of disease severity, as defined by the indications for home sleep apnea testing in the German guidelines \[15\]
* No active treatment during sleep recordings or within preceding two weeks (e.g., mandibular advancement devices, positive airway pressure therapy)
* Written informed consent obtained

Exclusion Criteria:

* Age \<18 years
* Known or suspected neurological sleep disorder (e.g., narcolepsy, parasomnia)
* Known or suspected psychiatric sleep disorder
* Known or suspected central and complex sleep apnea
* Participants who are unable to perform sleep measurements reliably
* Insufficient knowledge of the project language (German)
* Inability to give consent
* Shift workers (with shift work \<2 weeks before testing)

Where it's running

• Inselspital University Hospital and University Bern
  Bern, Switzerland Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.