Perioperative Myocardial Injury After Non-cardiac Surgery: Incidence and Outcomes
Official title: Basel Incidence, Patient Characteristics, Outcome and Possible Strategies to Improve Outcome of Perioperative Myocardial Injury After Non-cardiac Surgery: 1-Year Follow-up
Run by University Hospital, Basel, Switzerland · NCT02573532 · Data updated 2026-11-12
This study tests how often perioperative myocardial injury happens after major non-cardiac surgery and what outcomes follow, using hs-cTnT screening.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 45 Years and up |
| Sex | All |
| Enrollment | 19645 (estimated) |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 1 site (Basel, Canton of Basel-City) |
| Status | Recruiting |
| Started | October 2015 |
| Main results expected | December 2027 |
| Study ends | December 2027 |
| Registry record updated | September 28, 2026 |
| Trial ID | NCT02573532 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing major non-cardiac surgery who receive perioperative hs-cTnT screening and provide informed consent.
✕Probably not a fit
Patients who do not experience PMI or who do not have elevated hs-cTnT may not experience measurable benefits from the study's findings for their individual care.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study screens patients undergoing major non-cardiac surgery for perioperative myocardial injury (PMI) using high-sensitivity troponin T. It aims to describe PMI incidence, patient characteristics, underlying mechanisms, potential prevention and treatment options, and 1-year outcomes. The research will contextualize PMI within existing knowledge by comparing with baseline data and considering differences between PMI and spontaneous myocardial infarction. It acknowledges that many PMI events may be clinically silent, contributing to underdiagnosis and missed opportunities for intervention. The study is conducted at University Hospital Basel with collaboration from a Swiss partner and focuses on understanding PMI's scope and implications.
Why it matters
Potential benefit: If successful, the study could improve awareness, detection, and management of PMI, potentially reducing mortality and complications after non-cardiac surgery.
How similar studies have gone: Previous observational work suggests PMI is common and linked to adverse outcomes, but detailed etiologies and long-term results remain incompletely understood, making this study a valuable contribution.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria * Patients received a perioperative hs-cTnT screening for PMI * Patient consent available Exclusion criteria * Patient's refusal
Where it's running
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University Hospital Basel
Basel, Canton of Basel-City, Switzerland Recruiting
Study contacts
- Principal investigator: Christian Müller, MD, Prof — University Hospital, Basel, Switzerland
- Study coordinator: Christian Müller, MD, Prof
- Email: christian.mueller@usb.ch
- Phone: +41 61 328 6549
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Anesthesia-linked heart injury after non-cardiac surgery
This project will see if anesthesia and non-cardiac surgery are linked to increases in cardiac troponin (a marker of heart muscle injury) in adults aged 40–80 who have at least two cardiovascular risk factors.
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Landiolol to prevent fast heart rates during major non-cardiac surgery in patients with cardiovascular risk
This will test whether giving the ultra‑short acting beta‑blocker landiolol to people over 45 with cardiovascular risk factors who are having major non‑cardiac surgery can keep heart rate below 90 bpm throughout the perioperative period and reduce heart injury.
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Monitoring vital signs to understand heart issues after major surgery
This study is testing how monitoring vital signs and collecting blood samples can help us understand heart problems in high-risk patients after major surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.