Monitoring vital signs to understand heart issues after major surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the pathophysiology of perioperative myocardial infarction and injury in high-risk patients undergoing major non-cardiac surgeries. Participants will wear a wearable device to monitor vital signs for up to seven days post-surgery and provide blood samples at specified intervals. Additionally, they will complete a questionnaire one year after their surgery to gather long-term data. The study seeks to improve understanding of the various underlying causes of myocardial injury during the perioperative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient eligible for routine PMI-screening
* Patient requiring hospitalisation with ≥ 2 overnight stays after surgery
* Age ≥ 40 years to ≤ 85 AND history of coronary artery disease (CAD), peripheral artery disease (PAD), cerebrovascular disease/stroke, insulin-dependent diabetes mellitus (IDDM), or chronic heart failure (CHF)
* Elective surgery
* Patients undergoing orthopaedic, traumatology, vascular, spinal, thoracic, neurosurgical, urological or visceral surgery
* Patient consent available

Exclusion Criteria:

* Patient's refusal
* Heart surgery, cardiac arrest, acute mycardial infarction (AMI), cardiac valve intervention, or cardiac catheter ablation within 14 days prior to surgery OR involvement of heart surgery at index surgery OR surgery planned on cardiopulmonary bypass
* Patients undergoing plastic/reconstructive, ophthalmologic, dental, hand surgery, or ear-nose-and-throat surgery
* Chronic renal failure on dialysis, unless undergoing renal transplant surgery
* Moderate to severe dementia
* Inclusion into study within the last year

Where it's running

• University Hospital Basel
  Basel, Canton of Basel-City, Switzerland Recruiting

Study contacts

• Principal investigator: Christian Müller, MD, Prof — University Hospital, Basel, Switzerland
• Study coordinator: Christian Müller, MD, Prof
• Email: christian.mueller@usb.ch
• Phone: +41 61 328 6549

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Anesthesia-linked heart injury after non-cardiac surgery

  This project will see if anesthesia and non-cardiac surgery are linked to increases in cardiac troponin (a marker of heart muscle injury) in adults aged 40–80 who have at least two cardiovascular risk factors.

  Recruiting University Hospital Tuebingen · Tübingen · NCT07179029

• Landiolol to prevent fast heart rates during major non-cardiac surgery in patients with cardiovascular risk

  This will test whether giving the ultra‑short acting beta‑blocker landiolol to people over 45 with cardiovascular risk factors who are having major non‑cardiac surgery can keep heart rate below 90 bpm throughout the perioperative period and reduce heart injury.

  Recruiting Phase 4 Insel Gruppe AG, University Hospital Bern · Bern · NCT07168421

• Perioperative Myocardial Injury After Non-cardiac Surgery: Incidence and Outcomes

  This study tests how often perioperative myocardial injury happens after major non-cardiac surgery and what outcomes follow, using hs-cTnT screening.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT02573532

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.