Anesthesia-linked heart injury after non-cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study enrolling adults 40–80 undergoing elective or emergency non‑cardiac surgery with at least two cardiovascular risk factors and ASA II–IV. Researchers will obtain perioperative cardiac troponin measurements and collect clinical data to identify episodes of myocardial injury and their timing. The protocol excludes cardiac and obstetric procedures, minor surgeries not requiring anesthesia, and patients unable to give consent. Analyses will describe the frequency, timing (with attention to the first two postoperative days), and risk factors associated with perioperative myocardial injury.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Elective or emergency non-cardiac surgery
* Cardiovascular risk: At least two of the following: Age \>60 years, hypertension, diabetes mellitus, coronary heart disease, peripheral arterial occlusive disease, cerebrovascular disease, chronic renal insufficiency, chronic heart failure, chronic obstructive pulmonary disease, active smoking
* Age criteria: Adults aged 40-80 years.
* ASA status: ASA classification II-IV.
* Written consent after prior explanation

Exclusion Criteria:

* o Patients unable to give consent: intubated and sedated patients

  * Types of surgery: cardiac surgery, including coronary artery bypass grafting, heart valve repair or replacement, and heart transplantation; obstetric procedures, including cesarean section; minor surgical procedures that do not require general or regional anesthesia (e.g., minor dermatological or ophthalmological procedures)
  * Cardiovascular risk: patients without at least two of the following risk factors: age \<40 or \>80, no history of hypertension, diabetes, coronary artery disease, peripheral arterial disease, cerebrovascular disease, chronic renal failure, chronic heart failure, chronic obstructive pulmonary disease, and non-smoker status
  * Age criteria: Patients under 40 or over 80 years of age
  * ASA status: ASA classification of I.

Where it's running

• University Clinic of Tuebingen
  Tübingen, Germany Recruiting

Study contacts

• Principal investigator: Michael Koeppen, MD — University Clinic of Tuebingen
• Study coordinator: Michael Koeppen, MD
• Email: michael.koeppen@med.uni-tuebingen.de
• Phone: +497071-29 86935

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Landiolol to prevent fast heart rates during major non-cardiac surgery in patients with cardiovascular risk

  This will test whether giving the ultra‑short acting beta‑blocker landiolol to people over 45 with cardiovascular risk factors who are having major non‑cardiac surgery can keep heart rate below 90 bpm throughout the perioperative period and reduce heart injury.

  Recruiting Phase 4 Insel Gruppe AG, University Hospital Bern · Bern · NCT07168421

• Monitoring vital signs to understand heart issues after major surgery

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• Perioperative Myocardial Injury After Non-cardiac Surgery: Incidence and Outcomes

  This study tests how often perioperative myocardial injury happens after major non-cardiac surgery and what outcomes follow, using hs-cTnT screening.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT02573532

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.