Periodic lung recruitment during prone lumbar spine surgery to reduce atelectasis and improve breathing mechanics
Evaluation of the Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics in Elective Spine Surgery Using Lung Ultrasonography
This trial will test whether giving repeated lung recruitment maneuvers during elective lumbar spine surgery in adults keeps the lungs more open and improves breathing mechanics while under anesthesia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07325812 on ClinicalTrials.gov |
What this trial studies
This is a single-center, randomized controlled trial enrolling adults undergoing elective lumbar spine surgery in the prone position lasting at least two hours. Participants are randomized to receive periodic alveolar recruitment maneuvers throughout surgery versus the standard approach of recruitment only after positioning and before extubation. Intraoperative lung aeration will be monitored using lung ultrasonography and respiratory mechanics will be recorded to compare the two approaches. The trial excludes patients with BMI >30, chronic pulmonary disease, significant cardiac disease, pregnancy, or prior thoracic surgery.
Who should consider this trial
Good fit: Adults aged 18–65 with ASA physical status I–II scheduled for elective lumbar spine surgery in the prone position lasting at least two hours, with BMI ≤30 and no chronic lung or significant cardiac disease are ideal candidates.
Not a fit: Patients with BMI >30, known chronic pulmonary disease, significant cardiac disease, pregnancy, prior thoracic surgery, surgeries shorter than two hours, or those unable to consent are unlikely to qualify or benefit from this protocol.
Why it matters
Potential benefit: If successful, periodic recruitment maneuvers could reduce intraoperative atelectasis, improve oxygenation and respiratory mechanics, and potentially lower postoperative pulmonary complications.
How similar studies have performed: Some prior studies, including pediatric reports, suggest repeated recruitment maneuvers can better maintain lung aeration than single maneuvers, but evidence in adults undergoing prone spine surgery is limited and not definitive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 to 65 years * Scheduled for elective lumbar spine surgery under general anesthesia * Surgery planned to be performed in the prone position * Expected surgical duration of at least 2 hours * American Society of Anesthesiologists (ASA) physical status I-II * Ability to provide written informed consent Exclusion Criteria: * Body mass index (BMI) greater than 30 kg/m² * History of thoracic surgery * Known or suspected chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease) * Clinically significant cardiac disease * Pregnancy or breastfeeding * Known airway anomalies Intraoperative surgical duration shorter than 2 hours Refusal or inability to provide informed consent
Where this trial is running
Istanbul
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization — Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Serap KARACALAR, MD (Doctor of Medicine) — Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
- Study coordinator: Serap KARACALAR, MD (Doctor of Medicine)
- Email: skaracalar@yahoo.com
- Phone: +90 532 395 93 03
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.