Perforator flap vs full-th thickness skin graft after melanoma surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines two standard reconstruction methods used after margin re-excision in adults with stage II cutaneous melanoma. Patients are assigned to the reconstructive technique discussed at a melanoma multidisciplinary tumor board, reflecting real-world, current practice. Outcomes focus on healing, function, and aesthetics, without altering the cancer treatment plan. The observational design means there is no randomization or experimental intervention beyond standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult men or women (≥ 18 years)
* Patients with cutaneous melanoma of any stage (I, II, or III) according to the AJCC Cancer Staging Manual, 8th edition (2017), diagnosed prior to surgery
* Non-closable surgical defect after margin re-excision

Exclusion Criteria:

* Patients with microscopic or macroscopic nodal involvement when the sentinel lymph node has been removed
* Patients with distant metastases identified on ultrasound and/or CT scan and/or PET-CT, when performed
* Surgical contraindication to perforator flap reconstruction
* Pregnant or breastfeeding women
* Patients without health insurance coverage
* Vulnerable individuals: persons deprived of liberty, under legal guardianship, or under curatorship

Where it's running

• CHU Nantes-Department of Severe Burns and Aesthetic Surgery
  Nantes, Nantes, France Recruiting

Study contacts

• Principal investigator: Mathilde Gaudian — Nantes University Hospital
• Study coordinator: Ugo Lancien, MD
• Email: ugo.lancien@chu-nantes.fr
• Phone: 02 40 08 73 04

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.