Pediatric Epilepsies: How the illness progresses and affects thinking over time

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows patients with pediatric epilepsy seen at a single Italian center to describe how cognition evolves over time. Researchers will look for clinical and instrumental factors that predict cognitive function and its variation. The goal is to identify pathways and determinants that influence prognosis in pediatric epilepsies. There are no experimental interventions in this study; it relies on routine clinical data and follow-up. Results may help guide expectations and management for affected families.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients seen at the Children's Neuropsychiatry of the Fondazione Policlinico Gemelli IRCCS (UOS Diagnosis and Treatment of Drug-Resistant Epilepsies, Day Hospital or inpatient setting at the Department of Children's Neuropsychiatry) with onset of first seizure between the ages of 0 and 18 years and subsequent diagnostic confirmation of epilepsy (2 or more unprovoked seizures at least 24 hours apart or definite epilepsy syndrome, with diagnostic confirmation by the child neuropsychiatrist).
* Patients already followed at Child Neuropsychiatry with a diagnosis of epilepsy with age of onset between 0 and 18 years.
* Patients referred to our Center during follow-up with a diagnosis of epilepsy with age of onset between 0 and 18 years.

Exclusion Criteria:

* Patients with unconfirmed diagnosis of epilepsy after the first critical episode.
* Patients from other Centers, for whom the history, clinical and instrumental data are not sufficiently detailed and in accordance with the methodologies followed at our Center.
* Patients with follow-up \< 2 years.
* Patients for whom study consent is not provided.

Where it's running

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  Rome, Italy Recruiting

Study contacts

• Principal investigator: Domenica Immacolata Battaglia — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Domenica Immacolata Battaglia, MD
• Email: domenicaimmacolata.battaglia@policlinicogemelli.it
• Phone: +39 0630159222

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.