Pancreatic Surgery and New Diabetes Risk in Adults without Diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an ambispective, single-center observational study in Rome, assessing how different extents of pancreatectomy influence the development of new-onset diabetes and metabolic changes over 12 months. Researchers will use data from routine care, metabolic tests, imaging, and tissue samples to explore predictors and tissue characteristics that may relate to postoperative glycemic outcomes. The study includes retrospective, prospective, and mixed-cohort components for patients undergoing partial, near-total, or total pancreatectomy for benign or malignant disease. Primary goal is to determine the incidence of new-onset diabetes within a year after surgery, by resection type, with secondary aims on long-term glycemic trends and oncologic outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years)
* No diabetes mellitus at baseline
* Undergoing partial, near-total, or total pancreatectomy at the study center
* Availability of clinical and metabolic data according to study component
* Written informed consent for the prospective component

Exclusion Criteria:

* Diabetes mellitus at baseline
* Age \<18 years
* Missing key clinical data precluding eligibility assessment or primary outcome evaluation
* Refusal or inability to provide informed consent for the prospective component, where applicable

Where it's running

• Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  Rome, Italy Recruiting

Study contacts

• Principal investigator: Teresa Mezza — Fondazione Policlinico Universitario Agostino Gemelli IRCCS
• Study coordinator: Teresa Mezza, MD, PhD
• Email: teresa.mezza@policlinicogemelli.it
• Phone: 06 30156664

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.