Pain relief technique for laparoscopic kidney surgery

Application of Anterior Quadratus Lumborum Block at the Lateral Supra-arcuate Ligament Under Laparoscopic Direct Vision in Laparoscopic Renal Surgery：A Randomized, Controlled Trial

This study is testing a new pain relief technique for kidney surgery to see if it works better than the usual local anesthesia for helping patients feel less pain after their operation.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 66 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University (other)
• Locations: 1 site (Hangzhou, Zhejiang)
• Trial ID: NCT06550869 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the effectiveness of the Anterior Quadratus Lumborum Block performed under laparoscopic direct vision compared to traditional local infiltration anesthesia for managing postoperative pain in patients undergoing laparoscopic renal surgery. A total of 66 patients will be randomly assigned to either the experimental group receiving the new block technique or the control group receiving local anesthesia. The primary outcome will measure the total consumption of intravenous morphine equivalents within the first 24 hours post-surgery, while secondary outcomes will assess pain levels at various intervals. The study aims to provide a more effective pain management strategy for patients undergoing this type of surgery.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 80 who are undergoing laparoscopic nephrectomy or partial nephrectomy and have an ASA physical status classification of I to III.

Not a fit: Patients with severe renal failure, liver dysfunction, or those with a history of substance abuse or cognitive impairment may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce postoperative pain and opioid consumption for patients undergoing laparoscopic renal surgery.

How similar studies have performed: Other studies have shown promising results with similar analgesic techniques, suggesting potential for success in this approach.

Eligibility criteria

Inclusion Criteria:

* Age: 18 to 80 years old;
* American Society of Anesthesiologists (ASA) physical status classification: I to III;
* Undergoing laparoscopic nephrectomy or partial nephrectomy (including robotic-assisted laparoscopic nephrectomy and partial nephrectomy).

Exclusion Criteria:

* Recent use of anticoagulant medications or abnormal coagulation function;
* Local infection at the puncture site or the presence of tumors, severe deformities, or systemic infection;
* Severe renal failure (serum creatinine \> 442 μmol/L or requiring renal replacement therapy) or liver dysfunction (Child-Pugh Class C);
* Known allergy to local anesthetics or a family history of local anesthetic allergy;
* Preoperative cognitive impairment or inability to assess pain;
* Alcoholism, drug abuse, chronic opioid dependence, or the use of analgesics or psychotropic medications for more than 3 months;
* History of central and/or peripheral nervous system disorders or myasthenia gravis;
* Planned admission to the ICU;
* Surgical cancellation or patient refusal, etc.

Where this trial is running

Hangzhou, Zhejiang

• Second affiliated Hospital School of Medicine,Zhejiang University — Hangzhou, Zhejiang, China (RECRUITING)

Study contacts

• Study coordinator: Lina Yu, doctor

Conditions: Postoperative Pain, Analgesia, Quadratus Lumborum Block, Laparoscopic Renal Surgery