Ovulation Trigger Strategies for Women with Low Ovarian Reserve

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized Phase 3 trial compares three ovulation triggering methods in fresh IVF cycles for women with low ovarian reserve. Participants are assigned to hCG alone, hCG with follitropin delta, or a dual trigger with GnRH agonist plus hCG. The primary outcome is the number of mature oocytes retrieved; secondary outcomes include maturation rate and pregnancy outcomes after fresh embryo transfer. The study uses POSEIDON criteria to identify eligible women and evaluates safety alongside reproductive results. Results could inform optimized triggering strategies to improve oocyte yield and implantation in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed informed consent.
* Women aged between 18 and 42 years.
* Primary infertility.
* Women with low ovarian response classified within one of the groups defined by the POSEIDON criteria.

Exclusion Criteria:

* More than two previous failed ovarian stimulation cycles.
* Female age \>42 years.
* Body mass index (BMI) \>35 kg/m².
* Criteria of extremely low ovarian reserve according to the Spanish National Health System exclusion criteria (AMH \<0.3 ng/mL and/or antral follicle count \<5).
* Male partner age \>55 years.
* Severe male factor infertility (total motile sperm count \<1 million).
* Previous voluntary sterilization (vasectomy or bilateral tubal ligation).
* Previous healthy child shared by the couple.
* Presence of medical conditions contraindicating pregnancy.
* Risk of ovarian hyperstimulation syndrome (OHSS). If more than 15 follicles are expected on the day of trigger, the patient will be excluded from the study.

Where it's running

• Hospital Clínico Universitario de Valencia
  Valencia, Spain Recruiting

Study contacts

• Principal investigator: Cesar Lizan Tudela — Department of Obstetrics and Gynaecology, Hospital Clínico Universitario de Valencia
• Study coordinator: Cesar Lizan Tudela
• Email: cesarlizan@yahoo.es
• Phone: +34 96 197 3500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.