Using platelet rich plasma to improve ovarian response in women with poor fertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of autologous platelet rich plasma (PRP) intraovarian infusion to enhance ovarian response in women diagnosed with poor ovarian response (POR) during fertility treatments. The approach aims to restore the ovarian microenvironment by utilizing growth factors found in PRP, potentially improving the number of oocytes retrieved during stimulation cycles. The study will involve a large cohort of POR patients, focusing on their hormonal profiles and overall reproductive performance. It is designed as a non-randomized open-label intervention to gather comprehensive data on the efficacy of this treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following):

1. Age ≥ 40 years
2. AMH \< 1.1 ng/ml OR AFC \< 7
3. ≤ 3 oocytes with a conventional stimulation protocol

   * Discontinuation of any complementary/adjuvant treatment including hormone replacement and acupuncture, for at least three months prior to recruitment.
   * Willing to comply with study requirements

Exclusion Criteria:

* Any pathological disorder related to reproductive system anatomy
* Cycle irregularities
* Amenorrhea
* Endometriosis
* Adenomyosis
* Fibroids and adhesions
* Infections in reproductive system
* Current or previous diagnosis of cancer in reproductive system
* History of familiar cancer in reproductive system
* Severe male factor infertility
* Prior referral for Preimplantation Genetic Testing (PGT) -Ovarian inaccessibility -Endocrinological disorders (Hypothalamus-
* Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome)
* BMI\>30 kg/m2 or BMI\<18.5 kg/m2
* Systematic autoimmune disorders

Where it's running

• Genesis Athens Clinic
  Athens, Attica, Greece Recruiting

Study contacts

• Principal investigator: Agni Pantou, M.D — Genesis Athens Clinic
• Study coordinator: Agni Pantou, M.D
• Email: agni.pantou@genesisathens.gr
• Phone: +306974447702

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.