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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Oral Mucosa Healing After Gum Recession Treatment in Diabetic People

Official title: Oral Mucosa Wound Healing in Diabetic Patients. A Clinical Study on Closed Wounds

Run by University of Kentucky · NCT07470281 · Data updated 2026-11-12

This study tests how gingival recession treatment heals in people with diabetes compared with people without diabetes.

More Diabetes Mellitus trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment40 (estimated)
SponsorUniversity of Kentucky
Academic / other
Locations1 site (Lexington, Kentucky)
StatusRecruiting
StartedSeptember 18, 2026
Main results expectedApril 2029
Study endsApril 2030
Registry record updatedNovember 10, 2026
Trial IDNCT07470281 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) with gingival recession who are either diabetic (HbA1c > 7% or managed with medications) or non-diabetic and are candidates for gingival recession treatment.

Probably not a fit

Diabetic patients with poorly controlled comorbidities or conditions contraindicating surgery may derive little or no benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with gingival recession, including both diabetics and non-diabetics, receive a coronally advanced flap with connective tissue graft and are followed for 180 days. Researchers look at root coverage outcomes and how factors like the oral microbiome and inflammatory markers relate to healing in each group. Biological samples and patient questionnaires are collected at multiple time points to explore associations with clinical results. The study is conducted at the University of Kentucky College of Dentistry.

Why it matters

Potential benefit: If successful, the study could improve understanding of how diabetes affects gum healing after recession treatment and inform tailored care.

How similar studies have gone: Previous research in wound healing and dental procedures suggests diabetes can influence healing, but results in this specific gingival recession context are variable and this study adds comparative data.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* aged ≥ 18 years;
* non-diabetic and diabetic patients (HbA1c\>7% (American Diabetes Association 2025) managed with oral hypoglycemic agents or insulin;
* in the need of gingival recession treatment (RT1) in upper or lower arches with identifiable or restored cement-enamel junction (CEJ);
* periodontal stable (BoP ≤25%)(Lang et al. 2003);
* no morphological or pathological conditions in the palatal mucosa.

Exclusion Criteria:

* patients with cardiovascular, blood dyscrasias, and immunodeficiency that contraindicate surgical procedures;
* taking medications known to interfere with the wound healing process or that contraindicate the surgical procedure;
* Pregnancy/lactation (assessed via self-report);
* current opportunistic oral lesions that mainly colonize the palate region;
* subjects that have taken antibiotics within the last 3 months or need for antibiotic prophylaxis;
* prisoners;
* signs or symptoms of active extra-oral head and neck infection (swelling) as determined by a dentist at the time of evaluation;
* subjects who cannot read or speak English or Spanish, and do not agree to having the assistance of an interpreter

Where it's running

  • College of Dentistry - University of Kentucky
    Lexington, Kentucky, United States     Recruiting

Study contacts

  • Principal investigator: Mauro Santamaria, DDS, MS, PhD — University of Kentucky
  • Study coordinator: Dawn G Dawson
  • Email: dawn.dawson@uky.edu
  • Phone: 8593235409

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov ↗ Find more trials like this →
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.