Optimizing cefiderocol dosing after acute burn injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adult patients (18–80 years) with acute burn injuries and estimated creatinine clearance ≥60 mL/min will be enrolled at a single center. Each participant will receive cefiderocol per the chosen dosing regimen and six timed blood samples will be taken to measure drug concentrations. Noncompartmental pharmacokinetic analysis and Monte Carlo simulation will be used to model drug exposure and the probability of achieving the free time-above-MIC (fT>MIC) target for Pseudomonas aeruginosa. Daily safety monitoring will occur during the sampling period and patients with KDIGO ≥1 or known HIV/HBV infection are excluded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age ≥ 18 and ≤ 80 years old
* estimated CLCR (eCLCR) ≥ 60 mL/min via Cockcroft-Gault equation

Exclusion Criteria:

* KDIGO classification ≥ 1 at day of screening
* known HIV or HBV infection

Where it's running

• Regional One Health
  Memphis, Tennessee, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.