Optimizing Cancer Treatment with EPA-enriched Nutrition for Malnutrition

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, interventional trial investigates the role of EPA-enriched oral nutrition in malnourished adults with advanced lung or colorectal cancer who are undergoing or about to start systemic anti-cancer treatment. Participants must be at nutritional risk, have systemic inflammation, and meet other health criteria, then receive either an EPA-enriched nutrition product or standard care as part of cancer care. The study aims to see if this nutritional approach can improve weight, inflammatory status, and treatment tolerance. It is sponsored by the University of Edinburgh with collaboration from partner centers and industry, and it takes place at multiple European sites. Outcomes will inform whether EPA-enriched nutrition should be integrated into supportive care for malnourished cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants with stage III-IV lung and/or colorectal cancer undergoing systemic anti-cancer treatment (SACT) or starting SACT within the next 4 weeks \*with non-curative intent
* Participants aged 18 or older
* Participants at nutritional risk defined as a BMI \<20 kg/m2 and/or over 5% weight loss in the previous 6 months\*\*
* Participants with systemic inflammation within 28 days of screening (CRP \>10 mg/dL)
* Participants with an ECOG-PS\*\*\* score of 0, 1 or 2
* Participants willing and able to give written informed consent

Exclusion Criteria:

* Participants with a recent history of tumour resection (within 12 months)
* Participants with severe renal or hepatic failure or an intolerance to any of the ingredients of the study product
* Participants who are using dietary counselling, ONS or any form of artificial feeding at the time of recruitment
* Unable to adhere to either arm of the trial and appropriate requirements
* Contraindication to ONS including a lactose intolerance
* Females who are pregnant or of childbearing potential and not using adequate contraception

Where it's running

• Edinburgh Cancer Centre
  Edinburgh, United Kingdom Recruiting
• Gateshead NHS Trust
  Gateshead, United Kingdom Recruiting
• Clatterbridge Cancer Centre
  Liverpool, United Kingdom Recruiting
• Oslo University Hospital
  Oslo, Norway Not yet recruiting

Study contacts

• Study coordinator: Jessica Kelly
• Email: opt-epa@soton.ac.uk
• Phone: +442380599247

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Guaraná Supplement for Cancer-Related Fatigue in People Undergoing Treatment

  This study tests whether taking guaraná capsules helps reduce cancer-related fatigue and improve quality of life in adults with breast, lung, colorectal, or gastric cancer who are actively receiving treatment.

  Recruiting Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo · Bogotá, Bogota D.C. · NCT07816263

• Social prescriptions and micro-learning to improve cancer care

  This study tests a multicomponent program using social prescriptions and short online learning to help cancer patients and their chosen support persons in Germany.

  Recruiting University of Regensburg · Augsburg, Bavaria and 7 other locations · NCT07788729

• Personal health app in young-to-midlife adults in Hong Kong

  This trial tests whether the Wellnuts self-health assessment app helps asymptomatic adults in Hong Kong become more health-aware and proactive about care, compared with standard online health resources.

  Recruiting The University of Hong Kong · Hong Kong · NCT07720245

• Precision navigation to boost cancer screening participation in high-risk communities

  This study tests whether a personalized navigation program helps adults aged 45–74 in Chinese communities who are at high risk for several cancers to complete recommended free cancer screenings.

  Recruiting at 3 sites Hunan Cancer Hospital · Huaihua, Hunan and 2 other locations · NCT07676383

• LRRC15-targeted PET imaging for more precise diagnosis and staging of pancreatic, breast, lung, sarcoma and head-and-neck cancers

  This project tests whether an LRRC15-targeted PET scan can better detect and stage LRRC15-expressing cancers and measures how the tracer behaves in healthy adults.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07552467

• AI language tools to help tumor care teams write MDT reports

  We will test whether AI language tools can help junior cancer doctors write MDT diagnosis and treatment reports more accurately and faster.

  Recruiting at 2 sites Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong and 1 other locations · NCT07504367

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.