Opioid-sparing anesthesia to improve recovery after emergency abdominal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In adult patients undergoing emergency laparotomy, the study uses lidocaine and other non-opioid strategies to reduce opioid use during and after surgery. The protocol includes predefined fluid management, perioperative analgesia, and standardized postoperative paracetamol; the goal is to enhance recovery by minimizing opioid-related side effects. The approach builds on evidence from elective surgeries but evaluates applicability in urgent, non-elective settings. Recruitment is at Kasr Alainy Hospital under Cairo University, with specific inclusion and exclusion criteria to identify suitable participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (21-65 years), ASA I-III undergoing emergency laparotomy with midline incision

Exclusion Criteria:

* Severe cardiac morbidities (impaired contractility with ejection fraction \< 45%, heart block, arrhythmias, tight valvular lesions)
* Patients on vasopressor infusion, patients with high shock index (heart rate / systolic blood pressure \>1)
* Body mass index \<18 or \> 35 Kg/m2,
* Pregnant or lactating women,
* Allergy of any of the study drugs
* Severe liver cell failure and renal impairment by history and/or abnormal liver and kidney function tests.

Where it's running

• Kasr Alainy Hospital
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Maha Mostafa, MD
• Email: maha.mostafa@cu.edu.eg
• Phone: +201000365115

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.