Opioid-free anesthesia for bowel recovery after colorectal surgery
A Randomized Control Trial Evaluating the Utility of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
This study tests if using an opioid-free anesthesia during colorectal surgery can help patients recover faster and use less pain medication afterward.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Saskatchewan Academic / other |
| Locations | 1 site (Saskatoon, Saskatchewan) |
| Trial ID | NCT04144933 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of an opioid-free general anesthetic technique using medications like lidocaine, ketamine, dexmedetomidine, and magnesium on patients undergoing elective laparoscopic colorectal surgery. The study aims to compare this approach with traditional opioid-containing anesthesia to see if it reduces postoperative opioid use and accelerates the return of bowel function. By focusing on multimodal analgesia, the trial seeks to enhance recovery outcomes for patients.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old, classified as ASA class I-III, scheduled for elective laparoscopic colorectal surgery.
Not a fit: Patients who may not benefit include those undergoing emergency or open surgeries, or those with significant comorbidities or contraindications to the study medications.
Why it matters
Potential benefit: If successful, this approach could significantly reduce opioid consumption and improve recovery times for patients after colorectal surgery.
How similar studies have performed: Other studies have shown promising results with opioid-free anesthesia techniques, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18, American Society of Anesthesiology (ASA) class I-III patients scheduled for elective laparoscopic/laparoscopic assisted colorectal surgery Exclusion Criteria: * Emergency surgery, open surgery, contraindications to laparoscopic surgery (ie. adhesions, inability to tolerate pneumoperitoneum), American Society of Anesthesiology (ASA) class 4, age \< 18, pregnant or breastfeeding women, significant cardiorespiratory/hepatic/renal disease, allergy to any study drugs, inability to consent, inability to respond to pain assessments, inability to use the patient controlled analgesia device (PCA)
Where this trial is running
Saskatoon, Saskatchewan
- Royal University Hospital — Saskatoon, Saskatchewan, Canada (Recruiting)
Study contacts
- Study coordinator: Jonathan Gamble, MD
- Email: jonathan.gamble@saskhealthauthority.ca
- Phone: 306-655-1183
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.