One session of high-frequency rTMS to help with severe arm weakness after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses navigated TMS to map cortical motor activity before and after a single session of 10 Hz rTMS (600 pulses) delivered to the affected motor cortex, compared with sham stimulation, in stroke patients with severe upper limb impairment. The primary aim is to see if the rTMS session increases the number of motor-evoked potential positive points in the cortical map. Participants undergo a cortical motor mapping assessment, receive either real or sham stimulation, and then have a post-intervention mapping to detect any changes. The study addresses the gap in evidence for rTMS effectiveness in patients who are ME- P negative and have minimal voluntary hand function, considering mechanisms like diaschisis and latent corticospinal activity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* First-ever stroke confirmed by MRI or CT scan.
* Inability to voluntarily activate the hand musculature:

manual muscle testing score of 1 or less in finger extension.

* Time since stroke onset greater than 6 months.

Exclusion Criteria:

* History of craniotomy or metallic implants in the skull.
* Diagnosis of uncontrolled epilepsy.
* Diagnosis of other neurological diseases (dementia, Parkinson's disease, neuropathies, multiple sclerosis, or similar conditions).
* Low level of consciousness or significant cognitive impairment that prevents informed consent or study collaboration.
* Diagnosis of rheumatic disease or presence of hand deformities.
* Pregnancy.

Where it's running

• Hospital Sant Joan de Déu Palma
  Palma, Balearic Islands, Spain Recruiting

Study contacts

• Principal investigator: Ancor Rebassa Cabrera, PT, MSc — Hospital Sant Joan de Deu
• Study coordinator: Ancor Rebassa Cabrera, PT, MSc
• Email: ancor.rebassa@sjd.es
• Phone: +34 607832655

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

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  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

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  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.