Offering multiple PrEP options, including the dapivirine ring, to young women at reproductive health clinics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This stepped-wedge cluster randomized program will roll out a multi-product PrEP delivery model across 12 health clinics in Kiambu County, Kenya, enrolling about 1,400 adolescent girls and young women seeking reproductive health services. Clinics will be supported to add the dapivirine vaginal ring alongside existing daily oral PrEP services, and implementation will be staggered so sites transition from standard care to the multi-product offering over time. The primary outcome is whether making multiple PrEP products available increases initiation and persistence of HIV prevention among participants. Data will be collected during routine clinic visits and follow-up to compare uptake and continuation before and after the intervention at each site.

Why it matters

Who can join: the full rules

Inclusion Criteria for Adolescent Girls and Young Women seeking reproductive health services:

Age ≥18 years and ≤30years. Seeking a reproductive health service from one of the project facilities (reproductive health services include but are not limited to family planning, maternal and child health, postnatal care).

AGYW receiving reproductive health-related services through OPD, or other departments are eligible. AGYW receiving reproductive health-related services through other departments are eligible.

Willing and able to partake in an informed consent process. Able to speak and read in Kiswahili or English.

Where it's running

• Kenya Medical Research Institute and Partners in Health & Research Development
  Thika, Kiambu County, Kenya Recruiting

Study contacts

• Principal investigator: Nelly Mugo, MBChB, MMed, MPH — Kenya Medical Research Institute
• Study coordinator: Renee Heffron, PhD, MPH
• Email: rheffron@uabmc.edu
• Phone: 205-934-7349

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.