Observing patients with Cushing's syndrome before and after treatment
Official title: Effects of CORtisol Excess and REmission in Cushing's Syndrome Over Time (CORRECT): A Prospective Non-interventional Cohort Study
Run by University of Aarhus · NCT05521529 · Data updated 2026-11-12
This study looks at how Cushing's syndrome affects people's daily lives and health before and after they receive treatment to see if things get better.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus, State) |
| Status | Recruiting |
| Started | February 16, 2023 |
| Main results expected | October 2028 |
| Study ends | November 2032 |
| Registry record updated | April 4, 2025 |
| Trial ID | NCT05521529 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years old with a new diagnosis of Cushing's syndrome of endogenous origin.
✕Probably not a fit
Patients with active cancer, severe chronic diseases, or those unable to safely participate will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to prospectively evaluate patients diagnosed with Cushing's syndrome, focusing on their physical function, quality of life, and circadian rhythms both before and after treatment. The study hypothesizes that Cushing's syndrome adversely affects health-related quality of life and physical functioning, and that these issues may improve following effective treatment. By analyzing changes in circadian rhythms at the whole body level and in specific tissues, the study seeks to provide insights into the broader impacts of the syndrome and its management.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how Cushing's syndrome affects patients' lives and inform better treatment strategies.
How similar studies have gone: While the specific approach of this study is observational, similar studies have shown success in understanding the impacts of chronic conditions on quality of life.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * New (≤ 2 months) diagnosis of Cushing's syndrome (CS) of endogenous etiology: * ACTH-dependent CS * ACTH-independent CS * Age \>18 years * Written informed consent Exclusion Criteria: * Active cancer * Iatrogenic or malignant cause of CS such as adrenocortical carcinoma * Chronic heart failure (New York Heart Association class IV) * Chronic kidney disease Chronic Kidney Disease stage ≥3 (eGFR \>30 ml/min) * Liver disease in the form of cirrhosis * Deemed unable to complete the study safely by investigator
Where it's running
-
Department of Endocrinology and Internal Medicine
Aarhus, State, Denmark Recruiting
Study contacts
- Study coordinator: Simon Bøggild Hansen, MD
- Email: simhan@clin.au.dk
- Phone: 41111574
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Myokines in metabolic and endocrine diseases linked to sarcopenia
This study tests whether myokines can serve as biomarkers or drivers of sarcopenia and sarcopenic obesity in people with metabolic or endocrine diseases.
-
Osilodrostat for high blood pressure caused by Cushing's syndrome
This study tests whether osilodrostat can lower high blood pressure in adults with Cushing's syndrome-related hypercortisolemia.
-
Normal ranges and diagnostic cut-offs for salivary cortisol
This project will test two saliva cortisol methods — a lab LC‑MS assay and a rapid fluorescence immunoassay — to find normal ranges and the best diagnostic cut-offs for adults with suspected Cushing syndrome or adrenal insufficiency.
-
Using modified Desmopressin for better imaging in Cushing syndrome
This study is testing a new way to use a modified form of Desmopressin to improve imaging for people with Cushing syndrome, helping doctors better see and understand pituitary tumors before surgery.
-
Impact of Metyrapone on Heart Health in Patients with Adrenal Issues
This study is testing if Metyrapone can improve heart health and lower blood pressure in people with adrenal problems like incidentalomas and subclinical Cushing's syndrome.
-
Improving the Desmopressin test for diagnosing Cushing Syndrome
This study is testing a new way to use the Desmopressin test to better diagnose different types of Cushing syndrome in adults who might have the condition.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.