Observing brain activity in children under sevoflurane anesthesia
Official title: Electroencephalogram Study in Children Under Sevoflurane Anesthesia - a Prospective,Observational Study
Run by Second Affiliated Hospital of Wenzhou Medical University · NCT06580028 · Data updated 2026-11-12
This study looks at how sevoflurane anesthesia affects brain activity in young children aged 0 to 6 years to better understand its impact on their developing brains.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 1 Day to 6 Years |
| Sex | All |
| Enrollment | 280 (estimated) |
| Sponsor | Second Affiliated Hospital of Wenzhou Medical University Academic / other |
| Locations | 1 site (Wenzhou, Zhejiang) |
| Status | Recruiting |
| Started | September 4, 2024 |
| Main results expected | September 2026 |
| Study ends | September 2026 |
| Registry record updated | February 7, 2025 |
| Trial ID | NCT06580028 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 1 day to 6 years who require general anesthesia with sevoflurane and have a physical status classified as ASA I or II.
✕Probably not a fit
Patients with congenital malformations, severe health conditions, or recent upper respiratory infections may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the electroencephalogram (EEG) characteristics of children aged 0 to 6 years while under sevoflurane general anesthesia. Children will be divided into 14 age groups, with 20 participants in each group, to analyze the time-frequency characteristics of their prefrontal EEG. The study seeks to enhance understanding of how sevoflurane affects brain activity across different developmental stages. Informed consent will be obtained from parents or legal guardians before participation.
Why it matters
Potential benefit: If successful, this study could improve the safety and efficacy of anesthesia in young children by providing insights into their brain activity during procedures.
How similar studies have gone: While there have been studies on EEG under anesthesia, this specific approach focusing on sevoflurane in young children is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. aged 1 days#6 years#; 2. with American Society of Anesthesiologists (ASA) physical status I or II#; 3. children requiring general anesthesia under sevoflurane; 4. parents or legal guardians of children who volunteered to participate in the trial; And signed the informed consent form. Exclusion Criteria: 1. Congenital malformation or other genetic conditions that are thought to affect brain development ; 2. History of severe heart, brain, liver, kidney and metabolic diseases ; 3. Premature infants (≤32 weeks); 4. Upper respiratory tract infection in the last two weeks.
Where it's running
-
The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China Recruiting
Study contacts
- Principal investigator: Huacheng Liu — Second Affiliated Hospital of Wenzhou Medical University
- Study coordinator: Huacheng Liu
- Email: huachengliu@163.com
- Phone: 13957770577
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.