Sevoflurane (with or without IV lidocaine) versus propofol for intracranial pressure and brain oxygen during laparoscopic hysterectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants undergoing laparoscopic hysterectomy will receive either propofol total intravenous anesthesia, sevoflurane inhalational anesthesia, or sevoflurane with an intraoperative IV lidocaine infusion. Intracranial pressure will be estimated noninvasively using optic nerve sheath diameter and cerebral oxygenation will be monitored with cerebral oximetry at baseline, during pneumoperitoneum and Trendelenburg positioning, and after surgery. The trial compares perioperative changes in these measures across the three anesthetic approaches to determine which minimizes intracranial pressure increases and preserves cerebral oxygen delivery. All procedures and monitoring are performed at a single center with adult women meeting ASA I–II and BMI eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 18 to 65 years.
* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.
* Body mass index (BMI) ≤35.
* Females scheduled for laparoscopic hysterectomy.

Exclusion Criteria:

* Patients' refusal to participate in the study.
* Hypersensitivity and allergy to drugs of the study.
* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery
* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment
* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery
* If peak inspiratory pressure (PIP) exceeds 35.

Where it's running

• Tanta University
  Tanta, El-Gharbia, Egypt Recruiting

Study contacts

• Study coordinator: Eman A Elrefaey, Master
• Email: eman.elrefaey@med.tanta.edu.eg
• Phone: 00201008031402

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.