Observing blood sugar and lactate levels in patients with severe brain injuries
Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain Injury in the Intensive Care Unit - a Prospective, Observational Cohort Study
This study looks at how high blood sugar and lactate levels affect recovery in patients with severe brain injuries.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 875 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Rigshospitalet, Denmark Academic / other |
| Locations | 1 site (Copenhagen) |
| Trial ID | NCT05505396 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with severe acute brain injury to characterize the development of hyperglycemia and hyperlactatemia and their impact on clinical outcomes. It includes a subgroup of patients undergoing advanced multimodal neuromonitoring to explore the relationship between hyperglycemia and brain glucose levels, as well as systemic and microdialysis lactate. Blood and cerebrospinal fluid samples will be collected for analysis. The study aims to provide insights into how these metabolic markers influence recovery in brain injury patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have been admitted to the neurointensive care unit with a diagnosis of acute brain injury.
Not a fit: Patients who are brain dead prior to inclusion or whose relatives cannot communicate in Danish or English may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of metabolic disturbances in patients with severe brain injuries.
How similar studies have performed: While similar studies have explored metabolic disturbances in brain injury, this specific observational approach focusing on hyperglycemia and hyperlactatemia is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Admission to the neurointensive care unit at Rigshospitalet * Diagnosis of acute brain injury categorised as TBI, SAH, ICH, ischaemic stroke, or other conditions Exclusion Criteria: * Brain death before inclusion * Closest relatives do not understand written and spoken Danish or English
Where this trial is running
Copenhagen
- Department of Neuroanesthesiology and Neurointensive Care, Rigshospitalet — Copenhagen, Denmark (Recruiting)
Study contacts
- Study coordinator: Alexandra Vassilieva
- Email: alexandra.vassilieva@regionh.dk
- Phone: +4526525373
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.