Observing blood pressure changes after seizures in epilepsy patients
Observational Study on Dynamic Changes of Blood Pressure During Post-epileptic Seizure Stage: A Multicenter Study
This study looks at how blood pressure and heart rate change after seizures in people with epilepsy to better understand the risks involved.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2000 (estimated) |
| Ages | 14 Years to 80 Years |
| Sex | All |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06790810 on ClinicalTrials.gov |
What this trial studies
This multicenter observational study investigates the dynamic changes in blood pressure and heart rate during the post-epileptic seizure stage in patients with epilepsy. It aims to collect data on 2000 seizure events from hospitalized patients aged 14-80 years, focusing on the hemodynamic changes that occur after seizures. The study will gather information on blood pressure, heart rate, and blood oxygen levels at multiple time intervals post-seizure, alongside clinical details such as seizure type and medication use. The findings could provide valuable insights into the risks associated with postictal blood pressure fluctuations.
Who should consider this trial
Good fit: Ideal candidates include hospitalized epilepsy patients aged 14-80 years who have experienced at least one seizure during their stay.
Not a fit: Patients with structural heart disease, severe systemic diseases, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of postictal blood pressure changes, potentially reducing risks associated with epilepsy, including Sudden Unexpected Death in Epilepsy (SUDEP).
How similar studies have performed: While there is limited evidence on postictal blood pressure changes, this study aims to fill a significant gap in existing research, making it a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 14-80 years old, male and female; 2. Meet the diagnostic criteria for epilepsy, including focal epilepsy and generalized epilepsy. 3. Patients diagnosed with epilepsy, with at least one seizure during the hospitalization. 4. Seizures lasting longer than 30 seconds (including convulsive and non-convulsive status epilepticus, if seizure cessation can be determined and medications were recorded, they can be included). 5. Hypertensive patients who are on antihypertensive medication and have well-controlled blood pressure are eligible. 6. Patients who agree to participate in the study. Exclusion Criteria: 1. Patients with structural heart disease, coronary artery disease (CAD), cardiomyopathy 2. Patients with severe systemic diseases 3. Pregnancy 4. Preictal seizures or myoclonic seizures.
Where this trial is running
Beijing, Beijing
- Liankun Ren, MD — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Liankun Ren, MD — Study Principal Investigator
- Study coordinator: Liankun Ren, MD Ren, MD
- Email: renlk2022@outlook.com
- Phone: +86 13681576621
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.