Observational study on Polycystic Kidney Disease
Official title: The Baltimore Polycystic Kidney Disease Clinical and Translational Core Study
Run by University of Maryland, Baltimore · NCT01873235 · Data updated 2026-11-12
This study is trying to learn more about autosomal dominant polycystic kidney disease by gathering information from 350 adults to improve understanding of the disease and its effects on health.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | University of Maryland, Baltimore Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | March 2013 |
| Main results expected | June 2030 |
| Study ends | June 2030 |
| Registry record updated | September 11, 2025 |
| Trial ID | NCT01873235 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with a confirmed diagnosis of ADPKD and a glomerular filtration rate greater than 15 ml/min/1.73m2.
✕Probably not a fit
Patients with end-stage renal disease, those currently on dialysis, or individuals with other significant systemic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to establish a cohort of 350 adults with autosomal dominant polycystic kidney disease (ADPKD) to enhance understanding of the disease and its complications. Participants will undergo comprehensive clinical phenotyping, including assessments of kidney function, total kidney volume, and health-related quality of life. Additionally, a biobank will be created to store biological specimens for future research. The study will also develop an electronic registry for ADPKD patients interested in future clinical trials.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of ADPKD, potentially informing future therapeutic strategies.
How similar studies have gone: While this study builds on existing knowledge of ADPKD, it employs a novel approach to establish a comprehensive cohort and biobank, which has not been extensively tested in this manner.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Age 18 and older * ADPKD confirmed by genetic testing or ultrasound criteria using modified Ravine criteria: with family history:several cysts per kidney (3 by sonography, 5 if by computerized tomography or MRI)without family history: 10 cysts (by any radiologic method) per kidney and exclusion of other cystic kidney diseases * Ability to provide written informed consent prior to initiation of any study procedures and the ability in the opinion of the investigator to comply with all requirements of the study * Glomerular Filtration Rate (GFR) greater than 15ml/min/1.73m2 Exclusion Criteria: * End Stage Renal Disease or presently on dialysis or a prior kidney transplant --Pregnant, lactating, or intention to get pregnant in next 6 weeks * Another systemic disease such as cancer or lupus * Life expectancy less than 2 years * Current participation in a drug treatment trial * Non English speaking * Uncontrolled diabetes A1C 7.0 or more within 6 months of study visit; and/or on more than one oral hypoglycemic agent * Diabetic nephropathy
Where it's running
-
University of Maryland School of Medicine General Clinical Research Center
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Terry J Watnick, MD — University of Maryland, Baltimore
- Study coordinator: Charalett E Diggs, RN, MSN
- Email: charalett.diggs@som.umaryland.edu
- Phone: 410-706-2122
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Data collection for understanding Polycystic Kidney Disease
This study is collecting detailed health information from people with autosomal dominant polycystic kidney disease to better understand the condition and improve treatment options.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.