Observational study on early-stage polycystic kidney disease
Official title: Early PKD Observational Cohort Study
Run by University of Kansas Medical Center · NCT02936791 · Data updated 2026-11-12
This study is collecting samples from people with early-stage polycystic kidney disease and their family members to find signs that show how the disease is changing, which could help create new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 4 Years to 35 Years |
| Sex | All |
| Enrollment | 250 (estimated) |
| Sponsor | University of Kansas Medical Center Academic / other |
| Locations | 3 sites (Chicago, Illinois and 2 other locations) |
| Status | Recruiting |
| Started | April 2016 |
| Main results expected | June 2030 |
| Study ends | June 2031 |
| Registry record updated | April 27, 2026 |
| Trial ID | NCT02936791 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with early-stage autosomal dominant polycystic kidney disease and their unaffected siblings.
✕Probably not a fit
Patients with advanced kidney disease or those with systemic illnesses may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects blood, urine, and clinical information from individuals with early-stage polycystic kidney disease (PKD), their unaffected siblings, and normal volunteers to create a biobank. The goal is to identify biomarkers that indicate changes in disease progression, particularly focusing on early renal cyst growth. By understanding these biomarkers, the study aims to enhance the development of new therapies for PKD before significant kidney function decline occurs.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and better management of polycystic kidney disease, ultimately improving patient outcomes.
How similar studies have gone: Other studies have explored biomarkers in PKD, but this specific approach focusing on early-stage disease is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Inclusion for early stage autosomal dominant polycystic kidney disease (ADPKD): * Family history of PKD * All races and ethnic groups * Glomerular filtration rate (GFR) \>80 ml/min per 1.73 m2 * Inclusion for Healthy Volunteers: * Male or female with no family history of kidney disease * All races and ethnic groups * Normal GFR Exclusion Criteria: * Non-insulin or insulin-dependent diabetes mellitus * Systemic illness (i.e.systemic lupus erythematosus, vasculitis) * Unable to provide written informed consent * Unavailable for magnetic resonance imaging (MRI) and blood/urine collection
Where it's running
-
University of Chicago
Chicago, Illinois, United States Recruiting -
University of Kansas Medical Center
Kansas City, Kansas, United States Recruiting -
Children's Mercy Hospital
Kansas City, Missouri, United States Recruiting
Study contacts
- Principal investigator: Alan SL Yu, MD — University of Kansas Medical Center
- Study coordinator: Cathy Creed, RN
- Email: ccreed@kumc.edu
- Phone: 913-588-0053
Similar studies
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Observational study on Polycystic Kidney Disease
This study is trying to learn more about autosomal dominant polycystic kidney disease by gathering information from 350 adults to improve understanding of the disease and its effects on health.
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Data collection for understanding Polycystic Kidney Disease
This study is collecting detailed health information from people with autosomal dominant polycystic kidney disease to better understand the condition and improve treatment options.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.