Observational study on factors affecting chronic heart failure prognosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify the factors influencing the prognosis of chronic heart failure in patients. It will collect various omics data, including phenotype, environmental exposure, intestinal microbiome, genome, metabolome, and noninvasive biomarkers, to understand their impact on clinical outcomes. The study focuses on patients with specific types of cardiomyopathy and heart failure symptoms. By analyzing this data, researchers hope to gain insights into improving patient management and outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years;
2. Fulfill at least one of the following criteria：①History of chronic heart failure;②New-onset heart failure with LVEF \<50%；③New-onset heart failure with LVEF≧50%，E/e'≧15 and BNP\>400 pg/mL/NT-proBNP(\<50 years, \>450 pg/mL; 50\~75 years, \>900 pg/mL; \>75 years, \>1800 pg/mL)
3. Etiology: dilated cardiomyopathy, hypertensive heart disease, ischaemic cardiomyopathy, Non-severe valvular heart disease；
4. Primary post-discharge therapy: oral medication;
5. Sign the informed consent form.

Exclusion Criteria:

1. Patients with renal failure (Ccr\<30ml/min) or patients on dialysis therapy;
2. Various correctable secondary causes of cardiac insufficiency including hyperthyroid heart disease, anaemic heart disease, uncorrected congenital heart disease; severe valvular heart disease (including severe stenosis or closure of organic aortic and mitral valves);
3. Patients with indications for pacemaker implantation but have not received a pacemaker implant;
4. Patients with chronic obstructive pulmonary disease accompanied by type II respiratory failure.
5. Patients who cannot understand and sign an informed consent form.
6. Patients with mental illness, pregnant women, and other special populations.

Where it's running

• Taizhou People's Hospital affiliated to Nanjing Medical University
  Taizhou, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Ming Chu, Doctor — Jiangsu Taizhou People's Hospital
• Study coordinator: Yucheng Wu, Doctor
• Email: 2567181759@qq.com
• Phone: +8618360010750

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.