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Observational study on cardiovascular risk factors using non-invasive imaging

The Oxford Risk Factors And Non-Invasive Imaging Study

Observational University of Oxford · NCT05169333

This study is trying to see if new imaging techniques can help doctors better understand and predict heart and metabolic diseases in patients getting CT scans.

Quick facts

Study typeObservational
Enrollment250000 (estimated)
Ages18 Years to 99 Years
SexAll
SponsorUniversity of Oxford Academic / other
Locations37 sites (Bethesda, Maryland and 36 other locations)
Trial IDNCT05169333 on ClinicalTrials.gov

What this trial studies

The Oxford Risk Factors And Non-Invasive Imaging Study (ORFAN) is a prospective, multi-centre observational study aimed at developing and validating novel biomarkers for cardiometabolic diseases. It will collect CT scans, biological samples, and clinical outcomes data from unselected patients undergoing various CT scans at participating centers. By linking imaging data with patient demographics and clinical information, the study seeks to enhance diagnosis and risk prediction through advanced image analysis algorithms. Additionally, it will track disease progression and outcomes through follow-up scans and data collection.

Who should consider this trial

Good fit: Ideal candidates are males and females aged 18 to 99 who are undergoing CT scans and can provide informed consent.

Not a fit: Patients with active cancer or those unable to consent may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic tools and risk assessment for cardiovascular diseases.

How similar studies have performed: Other studies utilizing similar imaging and biomarker approaches have shown promise, indicating potential for success in this novel application.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

Inclusion Criteria for study Arms 1, 2 and 3:

* Participant is willing and able to give informed consent for participation in the study.
* Male or Female, aged 18 -99 years.

Inclusion Criteria for study Arm 4:

• Male or Female, aged 18 -99 years.

Exclusion Criteria:

Exclusion Criteria for Study Arms 1, 2 and 3:

* Unable or unwilling to consent
* Active cancer

Exclusion Criteria for Study Arm 4:

* Participation in Study Arms 1, 2 or 3
* Existing opt-out from use of data for research purposes

Where this trial is running

Bethesda, Maryland and 36 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cardiovascular DiseasesCardiovascular Risk Factors
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.