Investigating how sleep and circadian rhythms affect blood pressure in people with hypertension
Sleep and Circadian Mechanisms in Hypertension
This study is testing how sleep patterns and daily rhythms affect blood pressure in people with high blood pressure to see if a regular sleep schedule can help.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 32 (estimated) |
| Ages | 25 Years to 64 Years |
| Sex | All |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Trial ID | NCT05184933 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to explore the relationship between the circadian system, sleep, and non-dipping blood pressure in individuals with hypertension. Participants will undergo assessments of their sleep patterns in their home environment using polysomnography, followed by a laboratory protocol to analyze their circadian rhythms. The study includes a randomized crossover design to evaluate the effects of sleep versus wakefulness on blood pressure. Additionally, the trial will pilot the impact of a regularized sleep schedule over two weeks on 24-hour blood pressure measurements.
Who should consider this trial
Good fit: Ideal candidates are adults aged 25-64 with hypertension and a BMI between 18.5 and 42 kg/m².
Not a fit: Patients with severe sleep disorders, significant cardiovascular history, or those currently on certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for hypertension by optimizing sleep and circadian rhythms.
How similar studies have performed: While the specific approach of this study is novel, previous studies have indicated a potential link between sleep patterns and blood pressure regulation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 25-64 * BMI 18.5-42kg/m2 * Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg) Exclusion Criteria: * Over 5 pack-years of smoking; * Prior shift work within 12 months prior to the study; * Travel greater than three time zones for at least 3 months; * History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction; * Acute or chronic diseases (except hypertension) that may affect outcome measures; * History of psychological conditions; * Sleep disorders, like severe sleep apnea, insomnia, etc.; * Prescription medications (Contraceptives and anti-hypertensive medications are permissible); * History of Illicit drug use and alcohol dependency; * 30 days free of cannabis use prior to the study; * Pregnancy; * Upper cut-off of 160/100 mmHg for BP
Where this trial is running
Portland, Oregon
- Oregon Health and Science University — Portland, Oregon, United States (Recruiting)
Study contacts
- Principal investigator: Saurabh S Thosar, PhD — Oregon Health and Science University
- Study coordinator: Nicole Chaudhary, MPH
- Email: clinphys@ohsu.edu
- Phone: 5034945536
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.