Investigating how sleep and circadian rhythms affect blood pressure in people with hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to explore the relationship between the circadian system, sleep, and non-dipping blood pressure in individuals with hypertension. Participants will undergo assessments of their sleep patterns in their home environment using polysomnography, followed by a laboratory protocol to analyze their circadian rhythms. The study includes a randomized crossover design to evaluate the effects of sleep versus wakefulness on blood pressure. Additionally, the trial will pilot the impact of a regularized sleep schedule over two weeks on 24-hour blood pressure measurements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ages 25-64
* BMI 18.5-42kg/m2
* Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg)

Exclusion Criteria:

* Over 5 pack-years of smoking;
* Prior shift work within 12 months prior to the study;
* Travel greater than three time zones for at least 3 months;
* History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction;
* Acute or chronic diseases (except hypertension) that may affect outcome measures;
* History of psychological conditions;
* Sleep disorders, like severe sleep apnea, insomnia, etc.;
* Prescription medications (Contraceptives and anti-hypertensive medications are permissible);
* History of Illicit drug use and alcohol dependency;
* 30 days free of cannabis use prior to the study;
* Pregnancy;
* Upper cut-off of 160/100 mmHg for BP

Where it's running

• Oregon Health and Science University
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: Saurabh S Thosar, PhD — Oregon Health and Science University
• Study coordinator: Nicole Chaudhary, MPH
• Email: clinphys@ohsu.edu
• Phone: 5034945536

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.