Clinical trial Recruiting at 1 site Observational Ages 16 to 75

Observational study of neuroinflammation diseases in China

Official title: Prospective Cohort Study of cLinical and Imaging Patterns of neUroinflammation disEases (CLUE)

Run by Beijing Tiantan Hospital · NCT04106830 · Data updated 2026-11-12

This study is trying to see how brain and spinal cord changes in people with neuroinflammatory diseases can help us understand their condition better over a year of MRI scans.

Quick facts

Study typeObservational
Ages16 Years to 75 Years
SexAll
Enrollment1000 (estimated)
SponsorBeijing Tiantan Hospital
Academic / other
Drugs / interventionsRituximab
Locations1 site (Beijing, Beijing Municipality)
StatusRecruiting
StartedJanuary 1, 2019
Main results expectedDecember 31, 2027
Study endsDecember 31, 2028
Registry record updatedJune 15, 2026
Trial IDNCT04106830 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals aged 16-75 diagnosed with neuroinflammatory and demyelination diseases.

Probably not a fit

Patients who cannot undergo MRI due to contraindications or those currently participating in blinded clinical trials may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate structural and functional changes in the brain and spinal cord of patients with neuroinflammatory and demyelination diseases using advanced MRI techniques. Participants will undergo various MRI scans, including double inversion recovery and diffusion kurtosis imaging, over a one-year follow-up period. The goal is to better understand the inflammatory environment and its impact on disease progression and disability. This observational approach will help identify key biomarkers and imaging characteristics associated with these conditions.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic and monitoring strategies for patients with neuroinflammatory diseases.

How similar studies have gone: Other studies utilizing advanced MRI techniques have shown promise in understanding neuroinflammatory diseases, suggesting this approach may yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 16-75
* Diagnosis of neuroinflammatory and demyelination disease
* Availability of demographic and clinical data at the time disease onset
* Informed written consent obtained from the patient, and/or patient's parent(s), and/or legal representative. Assent, if old enough to grant, will be obtained from all patients under the age of 16 years.

Exclusion Criteria:

* Patients for whom MRI is contra-indicated
* Patients included in an ongoing clinical trial where the product is blinded

Where it's running

  • Beijing Tiantan Hospital
    Beijing, Beijing Municipality, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.