Observational study of neuroinflammation diseases in China
Official title: Prospective Cohort Study of cLinical and Imaging Patterns of neUroinflammation disEases (CLUE)
Run by Beijing Tiantan Hospital · NCT04106830 · Data updated 2026-11-12
This study is trying to see how brain and spinal cord changes in people with neuroinflammatory diseases can help us understand their condition better over a year of MRI scans.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years to 75 Years |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Drugs / interventions | Rituximab |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | January 1, 2019 |
| Main results expected | December 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | June 15, 2026 |
| Trial ID | NCT04106830 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 16-75 diagnosed with neuroinflammatory and demyelination diseases.
✕Probably not a fit
Patients who cannot undergo MRI due to contraindications or those currently participating in blinded clinical trials may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to investigate structural and functional changes in the brain and spinal cord of patients with neuroinflammatory and demyelination diseases using advanced MRI techniques. Participants will undergo various MRI scans, including double inversion recovery and diffusion kurtosis imaging, over a one-year follow-up period. The goal is to better understand the inflammatory environment and its impact on disease progression and disability. This observational approach will help identify key biomarkers and imaging characteristics associated with these conditions.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and monitoring strategies for patients with neuroinflammatory diseases.
How similar studies have gone: Other studies utilizing advanced MRI techniques have shown promise in understanding neuroinflammatory diseases, suggesting this approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 16-75 * Diagnosis of neuroinflammatory and demyelination disease * Availability of demographic and clinical data at the time disease onset * Informed written consent obtained from the patient, and/or patient's parent(s), and/or legal representative. Assent, if old enough to grant, will be obtained from all patients under the age of 16 years. Exclusion Criteria: * Patients for whom MRI is contra-indicated * Patients included in an ongoing clinical trial where the product is blinded
Where it's running
-
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Principal investigator: Yaou Liu, PhD — Beijing Tiantan Hospital
- Study coordinator: Yaou Liu, PhD
- Email: yaouliu80@163.com
- Phone: +86 1059975396
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.