Obesity and Muscle Signaling After a Single Workout and Protein Drink

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will compare how skeletal muscle responds to a bout of single-leg resistance exercise and a protein-rich drink in two groups: lean adults and adults with overweight or obesity. Participants will provide muscle samples from both legs before and after the activities to analyze signaling pathways related to muscle growth and autophagy. The study uses muscle biopsies, blood samples, a protein beverage, a resistance exercise session, and body composition assessments to understand group differences. Results may help tailor strategies to improve muscle quality in obesity. The project is conducted at the University of Birmingham with healthy adults in the defined age range and BMI categories.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age - 18-45yrs
* BMI - 18.5-24.9kg/m2 OR \>28kg/m2 (self-declaration, or calculated by research team based on height and weight)
* Weight Stable i.e. no change in weight of more than 5% in previous 6 months
* Meeting UK Physical activity guidelines (150 mins moderate or 75 mins vigorous activity/wk)
* Not involved in structured exercise training in previous 6 months
* No other diagnosed metabolic or neuromuscular conditions (self-declaration)

Exclusion Criteria:

* Currently using anti-diabetes medication (insulin, metformin, sulphonylureas, meglitinides, thiazolidinediones, DPP- 4 inhibitors, GLP-1 inhibitors).
* Currently taking cholesterol lowering medications (statins)
* Currently engaged in active weight loss programmes or using weight loss medication
* Chronic kidney disease (moderate to severe reduction in kidney function), defined as eGFR \<30 ml/min/1.73m2 identified by self declaration.
* Pregnant or breast feeding
* Currently using anti-coagulation medication
* Hypothyroidism
* Type 1 diabetes
* Current or recent weakness/injury to either leg that may affect muscle function or ability to exercise
* Current gastrointestinal issue/condition that may affect digestion and absorption of protein drink
* Individuals who follow a vegan diet or have intolerance/allergies to Whey protein.
* Previous adverse reaction to local anaethetic (lidocaine or marcaine).

Where it's running

• School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham
  Birmingham, United Kingdom Recruiting

Study contacts

• Principal investigator: Nathan Hodson — University of Birmingham
• Study coordinator: Jennifer Barrett, PhD
• Email: j.s.barrett@bham.ac.uk
• Phone: +447875713844

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.