Noninvasive optical-ultrasound imaging to look inside tissues

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates a light-and-ultrasound imaging approach (Ultrasound Optical Tomography, UOT) that uses non-ionizing radiation to probe tissue properties. The primary goal is to determine imaging depth and tissue information in healthy participants, laying groundwork for future cancer-related applications. The technique analyzes frequency-shifted light to achieve focus aligned with ultrasound, seeking better contrast than traditional optical methods. The study will also characterize tissue absorption and scattering and monitor safety related to laser exposure. Recruitment is limited to adults at Lund University in Malmö, with strict exclusion criteria to minimize skin-related risks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy individuals without systemic or skin-related conditions.
* Ability to provide informed consent.

Exclusion Criteria:

* Pregnancy: Although the risk that laser illumination on the skin may affect the fetus is minimal, we will exclude pregnant research subjects for safety.
* Skin diseases: Certain skin conditions can increase the risk of damage or complications when exposed to laser light, such as active rosacea, eczema, skin infections, or tattoos.
* Medication: Some medications can increase the sensitivity of the skin to laser light or increase the risk of side effects. It is important to consider the person's medical history and any ongoing treatments.
* Sunburn: Recent sun exposure of the skin may lead to increased sensitivity to laser light and can be more likely to experience discomfort or skin irritation/damage. This can both affect the reliability of the study and increase the risk of injury to the research subjects.
* History of keloid formation or scarring: People who have a history of excessive scarring may be more likely to react with greater skin irritation from the laser light.
* For breast measurements only: History of breast cancer or surgery. In this project, we aim to map the UOT signal only in healthy breast tissue.

Where it's running

• Lund University
  Malmö, Skåne County, Sweden Recruiting

Study contacts

• Principal investigator: Sophia Zackrisson, MD PhD — Lund University
• Study coordinator: Sophia Zackrisson, MD PhD
• Email: Sophia.zackrisson@med.lu.se
• Phone: +46736874149

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.