Investigating early breast growth in girls aged 6 to 8 years and its environmental influences

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to analyze the phenomenon of early breast development in girls aged 6 to 8 years, focusing on potential environmental factors contributing to this condition. The study will assess various parameters, including adipose tissue, metabolism, endocrine disruptors, and epigenetic modifications. By examining these factors, the trial seeks to understand the impact of environmental health measures on the progression of early puberty. Additionally, data from participants will be explored in experimental models to test potential mechanisms behind these observations.

Why it matters

Who can join: the full rules

For patients:

Inclusion Criteria:

* Girls aged 6 to 8 years
* Presenting a breast development (isolated or not)
* Undergoing scheduled pediatric day hospital care (HDJ)
* Who agree to participate in the study
* Whose parents agree to their child's participation in the study
* French speaking
* Whose parents speak French
* Affiliated to social security

Exclusion Criteria:

* Organic brain causes of precocious puberty: History of neurocerebral disease (malformations, developmental abnormalities)
* Organic causes of precocious puberty: Mac Cune Albright syndrome, ovarian cyst or tumor and adrenal hyperplasia
* History of chemotherapy or radiation therapy
* Presenting with a communication disorder
* Pregnancy
* Persons under protective measures
* Persons deprived of liberty for judicial or administrative reasons

For controls:

Inclusion Criteria:

* Girls aged 6 to 8
* Tanner stage 1: Absence of breasts and hairiness
* Coming for routine consultation in the pediatric HDJ at Saint-Vincent-de-Paul hospital, or at the BLM practice in Lambersart, or to radiology for an MRI for another medical other medical reason
* Agree to participate in the study
* Whose parents agree to their child's participation in the the study
* French-speaking
* Whose parents speak French
* Affiliated with social security

Exclusion Criteria:

* Signs of puberty (Tanner stages 2, 3, 4 and 5 for breast development) breast development)
* Previous chemotherapy or radiotherapy
* Presenting a communication disorder
* Pregnant women
* Persons under protective supervision
* Persons deprived of their liberty for judicial or administrative reasons

Where it's running

• Cabinet BLM
  Lambersart, Hauts-de-France, France Recruiting
• Saint Vincent hospital
  Lille, Hauts-de-France, France Recruiting

Study contacts

• Principal investigator: Patricia RANNAUD-BARTAIRE, PhD — Hôpital Saint-Vincent de Paul
• Study coordinator: Marie-Paule LEBITASY
• Email: lebitasy.marie-paule@ghicl.net
• Phone: 03.20.22.52.69

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.