Non-surgical laser treatment for peri-implantitis
Non-surgical Treatment of Peri-implantitis Using Combined Er: YAG (2940nm) and Diode Laser (808nm): a Randomized Controlled Clinical Trial. Clinical, Microbiological Parameters and Metabolomics
This study tests whether a new laser treatment for peri-implantitis works better than traditional ultrasonic cleaning for patients with this condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 36 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Aristotle University Of Thessaloniki Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Thessaloniki) |
| Trial ID | NCT06890117 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of non-surgical treatments for peri-implantitis by comparing conventional ultrasonic debridement with a laser-assisted approach. Patients diagnosed with peri-implantitis at the Postgraduate Periodontology Clinic of Aristotle University of Thessaloniki will be randomly assigned to receive either ultrasonic treatment or treatment with Er:YAG and Diode lasers. The study will assess clinical, microbiological, and metabolomic outcomes over a 3-month period, including pain levels and patient satisfaction. Microbial samples and peri-implant crevicular fluid will be collected for analysis before and after treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a diagnosis of peri-implantitis in at least one implant and no active periodontal disease.
Not a fit: Patients with uncontrolled systemic diseases, recent peri-implantitis treatment, or those who smoke may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a more effective and less invasive option for managing peri-implantitis.
How similar studies have performed: Other studies have shown promising results with laser-assisted treatments for periodontal conditions, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting at the Postgraduate Periodontology Clinic with a diagnosis of peri-implantitis in at least one implant, based on the 2018 classification of periodontal and peri-implant diseases (EFP 2018). Only implants with a probing pocket depth (PPD) of up to 10 mm will be included. Periodontally healthy individuals (no active periodontal disease). Implants must have been in function (loaded) for at least one year. Age ≥ 18 years. Medically healthy individuals or those with well-controlled systemic conditions. Implant-supported restorations must be accessible for proper oral hygiene. Patients must provide signed informed consent for participation in the study. Non-smokers only. Exclusion Criteria: * Presence of systemic diseases or medications that could influence treatment outcomes (e.g., uncontrolled diabetes, chemotherapy, immunosuppression). Underwent peri-implantitis treatment in the past 3 months. Use of antibiotics or antimicrobial therapy in the last 3 months. Pregnancy or breastfeeding. Smokers
Where this trial is running
Thessaloniki
- Aristotle University of Thessaloniki — Thessaloniki, Greece (Recruiting)
Study contacts
- Principal investigator: Chariklia Neofytou, MSc — Aristotle University Of Thessaloniki
- Study coordinator: Chariklia Neofytou, MSc
- Email: chneophytou04@gmail.com
- Phone: +306949160972
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.