New cardiac MRI technique using a specialized coil
The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field The TITAN Study
This study is testing a new MRI technique with a special coil to see if it can provide better images of heart tissue for both healthy people and those who have had heart attacks.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | University of Aberdeen Academic / other |
| Locations | 2 sites (Aberdeen, Aberdeenshire and 1 other locations) |
| Trial ID | NCT04458883 on ClinicalTrials.gov |
What this trial studies
This study aims to develop and test a cardiac-specific coil for Fast Field-Cycling MRI, a novel imaging technique that rapidly switches field strengths to provide detailed information about heart tissue. Researchers at the University of Aberdeen will create this coil and establish normal T1 dispersion curves for healthy hearts, while also distinguishing characteristics of scar tissue in patients who have experienced a myocardial infarction. The study will involve both healthy volunteers and patients with a history of heart attacks to assess the effectiveness of this new imaging approach.
Who should consider this trial
Good fit: Ideal candidates include healthy volunteers and patients diagnosed with a previous myocardial infarction.
Not a fit: Patients with claustrophobia, certain cardiac devices, or other undisclosed heart conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this technique could lead to improved cardiac imaging and better diagnosis of myocardial infarction and related conditions.
How similar studies have performed: While Fast Field-Cycling MRI is a novel approach, similar imaging techniques have shown promise in other studies, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant who is willing and able to give informed consent for participation in the study * Healthy volunteers willing to give informed consent for participation in the study * Patients diagnosed with a previous myocardial infarction Exclusion Criteria: * Unwillingness to participate * Claustrophobia * Contraindication to MRI scanning such as implantable cardiac devices * Participants who have had a previous myocardial infarction in the past of which they may not be aware and this is discovered whilst being scanned on the 3T MRI scanner, or who may have any other cardiology condition that they were previously unaware will not be included in the healthy control group, even if they present themselves to us as "healthy" at the time of the study visit * Pregnancy * Body habitus that may preclude comfortable positioning of the volunteer in either of the MRI scanners (\>50cm in diameter) * Participants with abnormal kidney function that will preclude them from receiving a contrast agent
Where this trial is running
Aberdeen, Aberdeenshire and 1 other locations
- Cardiovascular Research Facility — Aberdeen, Aberdeenshire, United Kingdom (Recruiting)
- University of Aberdeen and NHS Grampian — Aberdeen, Aberdeenshire, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Dana Dawson, DPhil — University of Aberdeen
- Study coordinator: James Ross, PhD
- Email: james.ross@abdn.ac.uk
- Phone: 01224437832
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.