Innate Immune Cells and Early Fibrotic Repair After a Heart Attack

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this observational study, 50 adults with STEMI undergoing PPCI will have blood samples analyzed for neutrophil and monocyte phenotypes, plus serum cytokines. Neutrophils will be sorted for transcriptome sequencing to explore gene expression patterns. At about one week after admission, participants will undergo cardiac MRI to measure the myocardial salvage index, LGE area, microvascular obstruction, extracellular volume, and LVEF to relate immune profiles to early fibrotic repair.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\---- Age \> 18 and ≤ 80 years old

\- Patients with acute STEMI within 12 hours of symptom onset who are planned to receive PPCI

Exclusion Criteria:

* Prior revascularization
* Known allergy to gadopentetate dimeglumine contrast agent
* Pregnancy or planned pregnancy within the next 6 months
* Life expectancy \< 1 year
* Metallic implants or claustrophobia that precluded MRI
* Severe COPD or inability to hold breath for MRI
* Severe hepatic or renal dysfunction (ALT \> 5×ULN or eGFR \< 15 mL/min/1.73 m²)

Where it's running

• Shanghai Tenth People's Hospital
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Jianhui Zhuang, MD
• Email: jh_zhuang@tongji.edu.cn
• Phone: 86-13621742833

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.