New biomarkers in pancreatic cancer using EXPEL concept
Official title: Discovery of New Biomarkers in Pancreatic Cancer Using Novel Nondestructive OMICS Methodology
Run by University Hospital, Montpellier · NCT03791073 · Data updated 2026-11-12
This study tests a non-destructive biomarker discovery method called EXPEL on patients with suspected pancreatic cancer to identify proteins, RNA, DNA, metabolites, and exosomes from interstitial tissue fluid.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier, Montpellier) |
| Status | Recruiting |
| Started | January 1, 2018 |
| Main results expected | January 1, 2019 |
| Study ends | November 1, 2027 |
| Registry record updated | June 18, 2026 |
| Trial ID | NCT03791073 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with a pancreatic mass suspected of PDAC who are undergoing endoscopic ultrasound with biopsy or surgical intervention and have not yet started pancreatic cancer treatment.
✕Probably not a fit
Patients whose samples do not yield informative biomarkers or who do not have PDAC may not receive a direct diagnostic or therapeutic benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will apply a modified EXPEL method during endoscopic ultrasound-guided biopsy or surgery to collect interstitial fluid from pancreatic tissue. The approach aims to enable comprehensive OMICS analyses from the same material used for clinical diagnosis, potentially revealing diagnostic and predictive biomarkers for PDAC. The study is observational and focuses on translating this liquid-biopsy-like collection into actionable biomarker data across disease stages. It leverages bioinformatics and systems biology to integrate multi-omics findings with clinical context. The investigation emphasizes non-destructive sampling to preserve tissue material for concurrent clinical evaluation.
Why it matters
Potential benefit: If successful, patients may gain access to biomarkers that improve diagnosis and help guide therapy decisions in pancreatic cancer.
How similar studies have gone: Previous approaches have shown potential in liquid-biopsy biomarker discovery, but the EXPEL-based method represents a novel integration with tissue-derived OMICS in pancreatic cancer.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with pancreatic mass and suspicion of pancreatic ductal adenocarcinoma requiring endoscopic ultrasound with fine needle biopsy or surgery * Patient ≥18 years old * Patient naïve of any treatment of Pancreatic cancer Exclusion Criteria: * Patient who reject the study protocol
Where it's running
-
Uhmontpellier
Montpellier, Montpellier, France Recruiting
Study contacts
- Study coordinator: Regis Souche, Md
- Email: fr-souche@chu-montpellier.fr
- Phone: 467337072
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.