Exploratory look at brain blood flow and metabolism before and after removing unruptured AVMs
Official title: Exploratory Study of Cerebral Perfusion and Metabolic Alterations and Neurocognitive Disorders in Patients With Unruptured Arteriovenous Malformations Before and After Surgical Treatment
Run by University Hospital, Montpellier · NCT07569887 · Data updated 2026-11-12
This study tests brain perfusion and metabolism with PET imaging and neuropsychological tests in adults before and six months after surgical treatment for unruptured brain AVMs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier, France) |
| Status | Recruiting |
| Started | June 16, 2026 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | July 7, 2026 |
| Trial ID | NCT07569887 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years and older with an unruptured AVM who are planned for surgical treatment and consent to PET imaging and neuropsychological testing.
✕Probably not a fit
Patients who do not experience measurable changes in perfusion or metabolism after surgery or who do not undergo surgery may not benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study describes how cerebral perfusion and metabolism change in various brain regions surrounding unruptured AVMs, measured with 18F-FDG PET and neuropsychological assessments. It follows an observational cohort over about 16 months to compare pre- and post-surgical states. Eligible participants are adults undergoing planned surgery for unruptured AVMs who consent to imaging and neuropsychological testing. The study is conducted at CHU de Montpellier in France and led by University Hospital, Montpellier. Results may improve understanding of how surgical intervention affects brain function and inform future treatment decisions.
Why it matters
Potential benefit: If successful, the study could improve understanding of brain changes after AVM surgery and help tailor patient care.
How similar studies have gone: Previous studies suggest perfusion and metabolic changes relate to symptoms, but detailed, prospective PET investigations in this specific setting are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 and older * Admitted for an unruptured arteriovenous malformation with a decision to proceed with surgery Exclusion Criteria: * Patients who refuse surgical treatment for arteriovenous malformation * Contraindications to 18F-FDG PET (uncontrolled diabete) * Patients' inability to lie still for 40 minutes * Patients with a confirmed diagnosis of neurodegenerative or psychiatric disorders * Pregnant or breastfeeding women (Article L.1121-5 of the French Public Health Code) * Persons deprived of their liberty by judicial or administrative decision (Article L.1121-6 of the French Public Health Code) * Persons who are subject to legal protection measures or who are unable to express their consent (guardianship, curatorship, judicial protection; Article L.1121-8 of the French Public Health Code) * Not affiliated with a social security scheme or beneficiary of such a scheme (Article L.1121-8-1 of the French Public Health Code) * Persons participating in another study that includes an ongoing exclusion period (Article L.1121-12 of the French Public Health Code) * Failure to obtain written informed consent
Where it's running
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CHU de Montpellier
Montpellier, France, France Recruiting
Study contacts
- Study coordinator: Lucas RIBEIRO, Dr
- Email: l-ribeiro@chu-montpellier.fr
- Phone: 0467337432
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.