Neurophysiological and Autonomic Responses to Acute Stress

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants experience four conditions in one session: resting baseline, cold pressor stress, negative memory recall, and affective picture viewing. EEG and autonomic signals (HR, HRV, EDA, SCR) are recorded, while subjective stress, anxiety, and pain are reported. The order of tasks is randomized or counterbalanced with recovery periods between conditions. The study uses a within-subject design to compare responses across conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 65 years.
* Ability to understand the study procedures and provide written informed consent.
* Sufficient knowledge of the Italian language to understand study instructions and complete the psychological assessments.

Exclusion Criteria:

* History of major neurological disorders or other medical conditions that could significantly affect EEG or autonomic measurements.
* Current severe psychiatric disorder that could interfere with participation in the experimental procedures.
* Cardiovascular conditions for which exposure to the Cold Pressor Test may be contraindicated.
* Medical conditions affecting peripheral circulation or sensitivity of the upper limbs that could interfere with or increase the risk associated with the Cold Pressor Test.
* Current use of medications that may substantially affect autonomic or central nervous system activity, when considered clinically relevant to the study procedures.
* Presence of wounds, injuries, or other conditions affecting the hand that would prevent safe completion of the Cold Pressor Test.
* Inability to complete the experimental procedures or provide valid informed consent.

Where it's running

• University of Pavia
  Pavia, Lombardy, Italy Recruiting

Study contacts

• Study coordinator: Teresa Fazia, PhD
• Email: teresa.fazia@unipv.it
• Phone: +390382987188

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.