Trehalose versus glycine air-polishing for peri-implant mucositis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial will enroll 40 adults with peri-implant mucositis who will be randomly assigned to non-surgical supportive therapy plus air-polishing with either trehalose (test) or glycine (control) powder. Clinical measures including Plaque Index, Bleeding on Probing, Probing Pocket Depth, and Bleeding Score will be recorded at baseline and at 1, 3, and 6 months to compare outcomes over time. The primary endpoint is reduction in plaque levels between groups, with secondary endpoints covering changes in gingival inflammation and probing depth. In addition, in vitro scanning electron microscopy will be used to examine implant surface effects of the powders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged between 18 and 70 years
* Presence of peri-implant mucositis, defined as bleeding on probing (BoP) around implants without radiographic evidence of bone loss beyond initial remodeling
* Visible biofilm on implant surfaces
* Ability to understand and sign informed consent
* Good oral hygiene and patient compliance
* Availability for all follow-up visits (1, 3, and 6 months)

Exclusion Criteria:

* Presence of systemic conditions that may affect healing (e.g., uncontrolled diabetes, immunosuppression)
* Current smokers or former smokers who quit less than 6 months ago
* Pregnant or breastfeeding women
* Use of antibiotics or anti-inflammatory drugs in the 3 months prior to baseline
* Presence of peri-implantitis (i.e., bleeding on probing with concomitant radiographic bone loss)
* History of head and neck radiotherapy
* Presence of pacemakers or cardiac stimulators
* Neurological or psychological disorders affecting study compliance

Where it's running

• Unit of Orthodontics and Pediatric Dentistry - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Pediatrics - University of Pavia
  Pavia, Lombardy, Italy Recruiting

Study contacts

• Principal investigator: Andrea Scribante, Associate Professor — University of Pavia
• Study coordinator: Andrea Scribante, Associate Professor
• Email: andrea.scribante@unipv.it
• Phone: +39 0382516223

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.