Neurological and systemic risks after locoregional anesthesia
Official title: Neurological Events and Unforeseen Risks After Locoregional-anesthesia
Run by Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva · NCT07238933 · Data updated 2026-11-12
This study tests how often nerve injuries, pneumothorax, and other complications occur after a single-shot regional nerve or fascial plane block in adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3396 (estimated) |
| Sponsor | Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva Academic / other |
| Locations | 4 sites (Bergamo, Bergamo and 3 other locations) |
| Status | Recruiting |
| Started | February 18, 2026 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2027 |
| Registry record updated | September 11, 2026 |
| Trial ID | NCT07238933 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 or older scheduled for a single-shot nerve or fascial plane block.
✕Probably not a fit
Patients receiving multiple blocks or catheter-based techniques are not expected to benefit from study findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter, prospective observational study collects data on complications following locoregional anesthesia, including nerve injury, hematoma, pneumothorax, and local anesthetic systemic toxicity. It focuses on single-shot blocks in upper and lower limbs and fascial plane blocks to estimate incidence and explore potential risk factors. Data are gathered from routine clinical care across several Italian centers, with standardized follow-up to identify both neurological and non-neurological events. The goal is to better understand the true safety profile of locoregional anesthesia and identify factors that may predict adverse outcomes.
Why it matters
Potential benefit: If successful, the study could provide clearer information on the risks of locoregional anesthesia to improve patient counseling and safety.
How similar studies have gone: Previous small studies and registries have suggested rare complications; this study aims to provide more robust, prospective incidence data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years. * Scheduled to undergo a single-shot nerve or fascial plane block. * Ability to provide written informed consent. Exclusion Criteria: * Performance of more than one single-shot nerve or fascial plane block within the same anatomical region or sensory distribution during the same procedure. * Use of continuous nerve or fascial plane catheter-based anesthesia. * Presence of a language barrier that, in the investigator's judgment, would prevent adequate follow-up.
Where it's running
-
Azienda Ospedale-Università Padova
Padova, Padova, Italy Recruiting -
ASST Papa Giovanni XXIII
Bergamo, Bergamo, Italy Not yet recruiting -
Spedali Civili di Brescia
Brescia, Brescia, Italy Not yet recruiting -
Irccs Humanitas Research Hospital
Rozzano, Milan, Italy Not yet recruiting
Study contacts
- Principal investigator: Alessandro De Cassai Prof., MD — UOC Istituto di Anestesia e Rianimazione, Azienda Ospedale Università di Padova
- Study coordinator: Cristina Cacciagrano Clinical Reasearch Office SIAARTI
- Email: ricerca@siaarti.it
- Phone: +39 06 4452816
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Lateral Quadratus Lumborum Block vs Intrathecal Morphine for Cesarean Section analgesia
This study tests whether a lateral quadratus lumborum block can provide pain relief after cesarean delivery as effectively as intrathecal morphine.
-
Impact of Communication Delays on Anesthesia Response in Medical Emergencies and Ultrasound-Guided Nerve Blocks
This study tests how an 80-second communication delay affects the speed and quality of regional anesthesia nerve blocks during emergencies in a spaceflight-like setting.
-
ESPB for persistent back pain in ankylosing spondylitis
This trial tests whether an erector spinae plane block can help reduce persistent back pain in adults with ankylosing spondylitis who still have pain despite controlled disease activity.
-
Comparison of meta-PENG vs suprainguinal fascia iliaca block for hip fracture pain
This study tests whether two ultrasound-guided nerve blocks help with pain control for adults having hip fracture surgery under spinal anesthesia.
-
Erector spinae plane block versus thoracoscopic intercostal nerve block for pain after VATS lung surgery
This compares two nerve-block techniques to see which gives better pain control after elective VATS lung surgery in adults.
-
Costoclavicular versus lateral-sagittal infraclavicular block for hand and forearm surgery
This study will see if the costoclavicular ultrasound-guided brachial plexus block produces a faster onset of numbness and motor block than the lateral-sagittal infraclavicular block in adults having hand or forearm surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.