Neurogenetics and cerebral blood flow in migraine with aura and patent foramen ovale

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

PFOCUS is a prospective case-control observational project that will enroll 240 adults with migraine with aura and classify them as PFO-positive or PFO-negative based on contrast-enhanced transcranial Doppler. Participants attend a single visit for collection of clinical and demographic data, blood samples for genetic and platelet analyses, and a comprehensive neurosonological assessment including microembolic signal counts and cerebrovascular reactivity testing. Genetic analysis will focus on NOTCH3 variants and selected SNPs linked to small-vessel function while hemodynamic testing will assess cerebral blood flow regulation. The combined genetic, platelet, and hemodynamic data are intended to clarify biological mechanisms linking PFO and migraine with aura and their potential contribution to cerebrovascular risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of migraine with aura (according to Chapter 1.2 of the International Classification of Headache Disorders, 3rd edition \[ICHD-3\])
* Age ≥ 18 years
* Both sexes
* Obtained written informed consent to participate in the study

Exclusion Criteria:

* History of congenital heart disease

Where it's running

• IRCCS Istituto delle Scienze Neurologiche di Bologna - AUSL of Bologna
  Bologna, Bo, Italy Recruiting

Study contacts

• Principal investigator: Matteo Paolucci — IRCCS Istituto delle Scienze Neurologiche di Bologna
• Study coordinator: Matteo Paolucci
• Email: matteo.paolucci@ausl.bologna.it
• Phone: +390513172087

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.