Nerve block technique to reduce knee pain after surgery

Posterior Femoral Cutaneous Nerve Combined With Proximal Sciatic and Saphenous Nerve Block for Postoperative Posterior Lateral Knee Analgesia in Patients With TKA: a Single-center, Prospective, Randomized Controlled Study

Not applicable Interventional General Hospital of Ningxia Medical University · NCT06522620

This study is testing a new way to block pain in the back of the knee after surgery to see if it helps people recovering from total knee replacement feel better and sleep more soundly.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment90 (estimated)
Ages45 Years to 80 Years
SexAll
SponsorGeneral Hospital of Ningxia Medical University Academic / other
Locations1 site (Yinchuan, Ningxia)
Trial IDNCT06522620 on ClinicalTrials.gov

What this trial studies

This study investigates the effectiveness of a posterior femoral cutaneous nerve block combined with sciatic and saphenous nerve blocks in reducing postoperative pain and improving sleep quality in patients undergoing total knee arthroplasty (TKA). The research aims to address the common issue of inadequate pain control after TKA, particularly focusing on pain in the posterior side of the knee. By comparing the combined nerve block approach to standard nerve blocks, the study seeks to enhance postoperative recovery for patients. Participants will be monitored for pain levels and sleep quality following the procedure.

Who should consider this trial

Good fit: Ideal candidates are patients over 45 years old, scheduled for elective first TKA under general anesthesia, with an ASA grade of II-III and a BMI less than 28 kg/m2.

Not a fit: Patients who have contraindications to nerve block operations or a history of allergy to local anesthetics or opioids may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve pain management and sleep quality for patients recovering from total knee arthroplasty.

How similar studies have performed: Previous studies have shown that combining multiple nerve blocks can be more effective for postoperative analgesia, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patients who are \>45 years of age; intended to undergo elective first TKA under general anesthesia
2. ASA grade II-III.
3. Agreed to participate in this study and signed the informed consent form.
4. BMI less than 28Kg/m2.

Exclusion Criteria:

1. Patients who refuse to participate in the trial
2. Preoperative inability to communicate due to speech and hearing impairment, etc.
3. History of allergy to local anesthetics or opioids
4. Contraindications to nerve block operation.

Where this trial is running

Yinchuan, Ningxia

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Postoperative PainPosterior Femoral Cutaneous NerveNerve BlockTKAposterior lateral knee pain
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.