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Clinical trial Recruiting at 1 site Observational Ages 18 and up

Natural history and prognostic factors of therapeutic response in sub-phenotypes of obesity

Official title: ASSESSMENT OF THE NATURAL HISTORY AND PROGNOSTIC FACTORS OF THERAPEUTIC RESPONSE IN SUB-PHENOTYPES OF PATIENTS WITH OBESITY: THE BOLOBE STUDY (BOLOgna for OBEsity Follow-up BOLOBE)

Run by IRCCS Azienda Ospedaliero-Universitaria di Bologna · NCT07666425 · Data updated 2026-11-12

This study follows adults with obesity or overweight to see how different subtypes respond to obesity therapies using data and machine learning.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment10000 (estimated)
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna
Academic / other
Locations1 site (Bologna, Bologna)
StatusRecruiting
StartedMay 30, 2026
Main results expectedMay 2036
Study endsMarch 2038
Registry record updatedJune 24, 2026
Trial IDNCT07666425 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) with BMI ≥ 30 kg/m² (or BMI ≥ 25 with at least one cardiometabolic comorbidity) who can provide informed consent.

Probably not a fit

Patients whose obesity is due to hypothalamic-pituitary or adrenal disorders or syndromic obesity may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center observational study that will collect retrospective and prospective data on patients diagnosed with obesity or overweight. The goal is to build prognostic and predictive models of how patients respond to obesity therapies, using statistical methods and machine learning for research purposes. Interim analysis will focus on the retrospective cohort with at least five years of follow-up from the start of data collection. Data will include laboratory results, treatments, and outcomes over time to identify factors associated with response. The study requires informed consent and excludes obesity caused by certain endocrine or syndromic conditions.

Why it matters

Potential benefit: If successful, the models could help predict which patients are more likely to respond to specific obesity therapies.

How similar studies have gone: Previous research in obesity has used observational data to develop predictive models, but this study applies machine learning to sub-phenotypes for prognosis and therapy response within a single center.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age ≥ 18 years
* Body mass index (BMI) ≥ 30 kg/m², or BMI ≥ 25 kg/m² with at least one cardiometabolic comorbidity
* Provision of written informed consent

Exclusion Criteria:

* Obesity secondary to hypothalamic-pituitary disorders
* Obesity secondary to adrenal disorders
* Syndromic obesity

Where it's running

  • IRCCS Azienda Ospedaliero - Universitaria di Bologna
    Bologna, Bologna, Italy     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Obese Adults 7Overweight , Obesity 31IRCCS Azienda Ospedaliero-Universitaria di Bologna 219
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.