Nasal cell collection to build a biobank for testing aerosol drugs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The project collects primary nasal epithelial cells from adults undergoing rhinologic surgery and grows them at the air–liquid interface to form a physiologic ex vivo model. The aim is to build a biobank of at least 60 samples and use these cells to study infection, inflammation, and potential aerosol therapies. This approach provides a human-relevant model that can reduce reliance on animal studies and help screen future aerosol drugs. The work focuses on maximizing cell yield, characterization, and context-specific testing conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (age \> 18 years) whose native language is French, or who understands French.
* Affiliation with a French social security system (CMU accepted).
* Informed consent, written and signed by the participant.
* Planned rhinological surgery (meatotomy, septoplasty or turbinoplasty for example, but other surgeries as well)

Exclusion Criteria:

* Patients under court protection, guardianship or curatorship.
* Pregnant or breast-feeding women (positive pregnancy test for women of childbearing age).
* Patients presenting a major alteration of the mucosa or a malignant rhinosinus pathology.

Where it's running

• Aussedat
  Tours, France Recruiting

Study contacts

• Study coordinator: Charles Aussedat, MD
• Email: c.aussedat@chu-tours.fr
• Phone: 0247474747

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.