Using dexmedetomidine to reduce agitation after nasal surgery
Effectiveness of Single Bolus Versus Continuous Infusion of Dexmedetomidine in Mitigating Agitation in Adults Undergoing Nasal Surgery: a Prospective Randomized Trial
This study is testing whether giving a single dose of dexmedetomidine can help reduce agitation in obese adults after nasal surgery compared to a continuous drip of the medication.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Fayoum University Hospital Academic / other |
| Locations | 1 site (Al Fayyum, Faiyum Governorate) |
| Trial ID | NCT06867302 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of a single bolus dose of dexmedetomidine versus a continuous infusion in reducing emergence agitation in obese adults undergoing nasal surgery. Emergence agitation can lead to serious complications, including self-injury and increased medical attention. The study focuses on adults, particularly those with risk factors such as obesity and ENT surgery, to evaluate how dexmedetomidine can mitigate these risks. Participants will receive dexmedetomidine in a saline solution before extubation to assess its impact on agitation levels.
Who should consider this trial
Good fit: Ideal candidates are obese adults with a BMI under 30 who are undergoing elective nasal surgery.
Not a fit: Patients with significant comorbidities, cognitive dysfunction, or those requiring intensive care post-surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of emergence agitation, leading to safer recovery and less need for additional medical interventions.
How similar studies have performed: While there have been studies on dexmedetomidine in pediatric populations, this approach in adults, particularly for nasal surgery, is less explored and may provide novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologist (ASA) Ⅰ or II * Adults with body mass index (BMI) \< 30 Kg/m * Underwent elective nasal surgery. Exclusion Criteria: * Significant comorbidity like hepatic, renal, or cardiac disease * Auditory impairment * Cognitive dysfunction * Substance abuse * Allergy to the studied medicines * Planned intensive care admission after the surgery.
Where this trial is running
Al Fayyum, Faiyum Governorate
- Fayoum University Hospital — Al Fayyum, Faiyum Governorate, Egypt (Recruiting)
Study contacts
- Principal investigator: Yasser S Mostafa, MD — Fayoum University
- Study coordinator: Yasser S Mostafa, MD
- Email: ysm03@fayoum.edu.eg
- Phone: 01010509735
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.