Using dexmedetomidine to reduce agitation after nasal surgery
Official title: Effectiveness of Single Bolus Versus Continuous Infusion of Dexmedetomidine in Mitigating Agitation in Adults Undergoing Nasal Surgery: a Prospective Randomized Trial
Run by Fayoum University Hospital · NCT06867302 · Data updated 2026-11-12
This study is testing whether giving a single dose of dexmedetomidine can help reduce agitation in obese adults after nasal surgery compared to a continuous drip of the medication.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Fayoum University Hospital Academic / other |
| Locations | 1 site (Al Fayyum, Faiyum Governorate) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | November 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT06867302 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are obese adults with a BMI under 30 who are undergoing elective nasal surgery.
✕Probably not a fit
Patients with significant comorbidities, cognitive dysfunction, or those requiring intensive care post-surgery may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare the effectiveness of a single bolus dose of dexmedetomidine versus a continuous infusion in reducing emergence agitation in obese adults undergoing nasal surgery. Emergence agitation can lead to serious complications, including self-injury and increased medical attention. The study focuses on adults, particularly those with risk factors such as obesity and ENT surgery, to evaluate how dexmedetomidine can mitigate these risks. Participants will receive dexmedetomidine in a saline solution before extubation to assess its impact on agitation levels.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of emergence agitation, leading to safer recovery and less need for additional medical interventions.
How similar studies have gone: While there have been studies on dexmedetomidine in pediatric populations, this approach in adults, particularly for nasal surgery, is less explored and may provide novel insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologist (ASA) Ⅰ or II * Adults with body mass index (BMI) \< 30 Kg/m * Underwent elective nasal surgery. Exclusion Criteria: * Significant comorbidity like hepatic, renal, or cardiac disease * Auditory impairment * Cognitive dysfunction * Substance abuse * Allergy to the studied medicines * Planned intensive care admission after the surgery.
Where it's running
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Fayoum University Hospital
Al Fayyum, Faiyum Governorate, Egypt Recruiting
Study contacts
- Principal investigator: Yasser S Mostafa, MD — Fayoum University
- Study coordinator: Yasser S Mostafa, MD
- Email: ysm03@fayoum.edu.eg
- Phone: 01010509735
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.