Myokines and exercise after breast cancer treatment
Official title: Myo-EXERTBC: A Pilot Study Assessing Myokines During an EXErcise Regimen After Treatment for Breast Cancer
Run by Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · NCT07698314 · Data updated 2026-11-12
This pilot study tests how different resistance exercise programs affect myokine production in women who have completed breast cancer treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 89 Years |
| Sex | Women only |
| Enrollment | 21 (estimated) |
| Sponsor | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy, radiation |
| Locations | 2 sites (Pittsburgh, Pennsylvania and 1 other locations) |
| Status | Recruiting |
| Started | July 6, 2026 |
| Main results expected | July 2027 |
| Study ends | July 2028 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07698314 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 20–89 who have completed breast cancer treatment and have prior supervised resistance training experience and are prescribed exercise as standard of care.
✕Probably not a fit
Women currently undergoing cytotoxic chemotherapy or unable to safely participate in group resistance training may be less likely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional pilot study will compare several resistance training regimens to see how they influence myokine production in women with a history of breast cancer. Participants are women aged 20 to 89 who have completed treatment and have at least three months of guided resistance training experience. The exercise programs include conditioning, strength, and hypertrophy resistance training, delivered in group sessions at the Allegheny Health Network Exercise Oncology Center. Immunotherapy or targeted agents are allowed, but active cytotoxic chemotherapy is not permitted during participation.
Why it matters
Potential benefit: If successful, the study could clarify how different resistance exercise prescriptions influence myokine responses, potentially informing personalized exercise plans for breast cancer survivors.
How similar studies have gone: Prior studies in exercise oncology have shown that exercise can modulate myokines, but this specific comparison of regimens in breast cancer survivors is exploratory and relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 20-89 years 2. Women prescribed exercise as a SOC 3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast 4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed. 5. Women with \> 3 months of resistance training experience under expert guidance at the Allegheny Health Network Exercise Oncology Center Exclusion Criteria: 1. Any current treatment with cytotoxic chemotherapy for breast cancer 2. Inability to safely engage in group sessions of resistance training as deemed by study PI 3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training 4. Pregnant women 5. Males
Where it's running
-
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States Recruiting -
AHN Allegheny General Hospital
Pittsburgh, Pennsylvania, United States Not yet recruiting
Study contacts
- Principal investigator: Colin Champ, MD — AHN Radiation Oncology
- Study coordinator: Clinical Trials Contact
- Email: ctgov@ahn.org
- Phone: 412-330-6151
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.